Perforin and IFN- gamma do not significantly regulate the virus-specific CD8 super(+) T cell response in the absence of antiviral effector activity

Using gene-targeted mice we have investigated whether perforin and/or interferon- gamma exert a direct regulatory effect on the expansion and contraction of antigen-specific CD8 super(+) T cells following infection with a virus (vesicular stomatitis virus) which is not controlled through these molec...

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Bibliographic Details
Published in:European journal of immunology 2004-01, Vol.34 (5), p.1389-1394
Main Authors: Christensen, Jeanette E, Wodarz, Dominik, Christensen, Jan P, Thomsen, Allan R
Format: Article
Language:English
Subjects:
Vesicular stomatitis virus
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Summary:Using gene-targeted mice we have investigated whether perforin and/or interferon- gamma exert a direct regulatory effect on the expansion and contraction of antigen-specific CD8 super(+) T cells following infection with a virus (vesicular stomatitis virus) which is not controlled through these molecular effector systems. Unlike what has been observed when these molecules are essential for pathogen clearance, neither molecule was found to play an important role in regulating the kinetics of the virus-specific CD8 super(+) T cell response in the absence of antiviral effector activity.
ISSN:0014-2980
DOI:10.1002/eji.200424858