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Broad-Spectrum Liquid- and Gas-Phase Decontamination of Chemical Warfare Agents by One-Dimensional Heteropolyniobates
A wide range of chemical warfare agents and their simulants are catalytically decontaminated by a new one‐dimensional polymeric polyniobate (P‐PONb), K12[Ti2O2][GeNb12O40]⋅19 H2O (KGeNb) under mild conditions and in the dark. Uniquely, KGeNb facilitates hydrolysis of nerve agents Sarin (GB) and Soma...
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Published in: | Angewandte Chemie International Edition 2016-06, Vol.55 (26), p.7403-7407 |
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creator | Guo, Weiwei Lv, Hongjin Sullivan, Kevin P. Gordon, Wesley O. Balboa, Alex Wagner, George W. Musaev, Djamaladdin G. Bacsa, John Hill, Craig L. |
description | A wide range of chemical warfare agents and their simulants are catalytically decontaminated by a new one‐dimensional polymeric polyniobate (P‐PONb), K12[Ti2O2][GeNb12O40]⋅19 H2O (KGeNb) under mild conditions and in the dark. Uniquely, KGeNb facilitates hydrolysis of nerve agents Sarin (GB) and Soman (GD) (and their less reactive simulants, dimethyl methylphosphonate (DMMP)) as well as mustard (HD) in both liquid and gas phases at ambient temperature and in the absence of neutralizing bases or illumination. Three lines of evidence establish that KGeNb removes DMMP, and thus likely GB/GD, by general base catalysis: a) the k(H2O)/k(D2O) solvent isotope effect is 1.4; b) the rate law (hydrolysis at the same pH depends on the amount of P‐PONb present); and c) hydroxide is far less active against the above simulants at the same pH than the P‐PONbs themselves, a critical control experiment.
POM against CWAs: A new one‐dimensional polymeric polyniobate, K12[Ti2O2][GeNb12O40], removes a wide range of chemical warfare agents (CWAs) and their simulants. The transformations are catalytic and proceed effectively under very mild conditions and in the dark. |
doi_str_mv | 10.1002/anie.201601620 |
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POM against CWAs: A new one‐dimensional polymeric polyniobate, K12[Ti2O2][GeNb12O40], removes a wide range of chemical warfare agents (CWAs) and their simulants. The transformations are catalytic and proceed effectively under very mild conditions and in the dark.</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.201601620</identifier><identifier>PMID: 27061963</identifier><identifier>CODEN: ACIEAY</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>Ambient temperature ; Biological & chemical weapons ; Catalysis ; Chemical warfare ; Chemical warfare agents ; Decontamination ; heteropolyniobates ; Hydrolysis ; Illumination ; Isotope effect ; Mustard ; Nerve agents ; Neutralizing ; Sarin ; Soman ; Temperature effects ; Vapor phases</subject><ispartof>Angewandte Chemie International Edition, 2016-06, Vol.55 (26), p.7403-7407</ispartof><rights>2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5460-957b1c130e9b516aff8f515ed3717cb5d990fda4c7edc1e37a4f3a9745cd73e63</citedby><cites>FETCH-LOGICAL-c5460-957b1c130e9b516aff8f515ed3717cb5d990fda4c7edc1e37a4f3a9745cd73e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27061963$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, Weiwei</creatorcontrib><creatorcontrib>Lv, Hongjin</creatorcontrib><creatorcontrib>Sullivan, Kevin P.</creatorcontrib><creatorcontrib>Gordon, Wesley O.</creatorcontrib><creatorcontrib>Balboa, Alex</creatorcontrib><creatorcontrib>Wagner, George W.</creatorcontrib><creatorcontrib>Musaev, Djamaladdin G.</creatorcontrib><creatorcontrib>Bacsa, John</creatorcontrib><creatorcontrib>Hill, Craig L.</creatorcontrib><title>Broad-Spectrum Liquid- and Gas-Phase Decontamination of Chemical Warfare Agents by One-Dimensional Heteropolyniobates</title><title>Angewandte Chemie International Edition</title><addtitle>Angew. Chem. Int. Ed</addtitle><description>A wide range of chemical warfare agents and their simulants are catalytically decontaminated by a new one‐dimensional polymeric polyniobate (P‐PONb), K12[Ti2O2][GeNb12O40]⋅19 H2O (KGeNb) under mild conditions and in the dark. Uniquely, KGeNb facilitates hydrolysis of nerve agents Sarin (GB) and Soman (GD) (and their less reactive simulants, dimethyl methylphosphonate (DMMP)) as well as mustard (HD) in both liquid and gas phases at ambient temperature and in the absence of neutralizing bases or illumination. Three lines of evidence establish that KGeNb removes DMMP, and thus likely GB/GD, by general base catalysis: a) the k(H2O)/k(D2O) solvent isotope effect is 1.4; b) the rate law (hydrolysis at the same pH depends on the amount of P‐PONb present); and c) hydroxide is far less active against the above simulants at the same pH than the P‐PONbs themselves, a critical control experiment.
POM against CWAs: A new one‐dimensional polymeric polyniobate, K12[Ti2O2][GeNb12O40], removes a wide range of chemical warfare agents (CWAs) and their simulants. The transformations are catalytic and proceed effectively under very mild conditions and in the dark.</description><subject>Ambient temperature</subject><subject>Biological & chemical weapons</subject><subject>Catalysis</subject><subject>Chemical warfare</subject><subject>Chemical warfare agents</subject><subject>Decontamination</subject><subject>heteropolyniobates</subject><subject>Hydrolysis</subject><subject>Illumination</subject><subject>Isotope effect</subject><subject>Mustard</subject><subject>Nerve agents</subject><subject>Neutralizing</subject><subject>Sarin</subject><subject>Soman</subject><subject>Temperature effects</subject><subject>Vapor phases</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqF0cFv0zAUBvAIgdgYXDkiS1y4uNhx7Rcfu250k6ptoqAdLcd5YR5J3NmJoP89njoqxAEkS_bh9z5Z7yuKt5zNOGPlRzt4nJWMq3xK9qw45rLkVACI5_k9F4JCJflR8Sql--yriqmXxVEJTHGtxHExncZgG7rZohvj1JO1f5h8Q4kdGrKyid7c2YTkDF0YRtv7wY4-DCS0ZHmHvXe2I7c2tjYiWXzDYUyk3pHrAemZ73FI2WZxgSPGsA3dbvChtiOm18WL1nYJ3zzdJ8XXT-dflhd0fb26XC7W1Mm5YlRLqLnjgqGuJVe2batWcomNAA6ulo3WrG3s3AE2jqMAO2-F1TCXrgGBSpwUH_a52xgeJkyj6X1y2HV2wDAlw0FDpZQUZabv_6L3YYr5-1lpVpUgQfN_KtAK8t65yGq2Vy6GlCK2Zht9b-POcGYeazOPtZlDbXng3VPsVPfYHPjvnjLQe_DDd7j7T5xZXF2e_xlO97M-jfjzMGvjd6NAgDS3VyuzWZ9-voGNMlL8AgPessE</recordid><startdate>20160620</startdate><enddate>20160620</enddate><creator>Guo, Weiwei</creator><creator>Lv, Hongjin</creator><creator>Sullivan, Kevin P.</creator><creator>Gordon, Wesley O.</creator><creator>Balboa, Alex</creator><creator>Wagner, George W.</creator><creator>Musaev, Djamaladdin G.</creator><creator>Bacsa, John</creator><creator>Hill, Craig L.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20160620</creationdate><title>Broad-Spectrum Liquid- and Gas-Phase Decontamination of Chemical Warfare Agents by One-Dimensional Heteropolyniobates</title><author>Guo, Weiwei ; Lv, Hongjin ; Sullivan, Kevin P. ; Gordon, Wesley O. ; Balboa, Alex ; Wagner, George W. ; Musaev, Djamaladdin G. ; Bacsa, John ; Hill, Craig L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5460-957b1c130e9b516aff8f515ed3717cb5d990fda4c7edc1e37a4f3a9745cd73e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Ambient temperature</topic><topic>Biological & chemical weapons</topic><topic>Catalysis</topic><topic>Chemical warfare</topic><topic>Chemical warfare agents</topic><topic>Decontamination</topic><topic>heteropolyniobates</topic><topic>Hydrolysis</topic><topic>Illumination</topic><topic>Isotope effect</topic><topic>Mustard</topic><topic>Nerve agents</topic><topic>Neutralizing</topic><topic>Sarin</topic><topic>Soman</topic><topic>Temperature effects</topic><topic>Vapor phases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guo, Weiwei</creatorcontrib><creatorcontrib>Lv, Hongjin</creatorcontrib><creatorcontrib>Sullivan, Kevin P.</creatorcontrib><creatorcontrib>Gordon, Wesley O.</creatorcontrib><creatorcontrib>Balboa, Alex</creatorcontrib><creatorcontrib>Wagner, George W.</creatorcontrib><creatorcontrib>Musaev, Djamaladdin G.</creatorcontrib><creatorcontrib>Bacsa, John</creatorcontrib><creatorcontrib>Hill, Craig L.</creatorcontrib><collection>Istex</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, Weiwei</au><au>Lv, Hongjin</au><au>Sullivan, Kevin P.</au><au>Gordon, Wesley O.</au><au>Balboa, Alex</au><au>Wagner, George W.</au><au>Musaev, Djamaladdin G.</au><au>Bacsa, John</au><au>Hill, Craig L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Broad-Spectrum Liquid- and Gas-Phase Decontamination of Chemical Warfare Agents by One-Dimensional Heteropolyniobates</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew. Chem. Int. Ed</addtitle><date>2016-06-20</date><risdate>2016</risdate><volume>55</volume><issue>26</issue><spage>7403</spage><epage>7407</epage><pages>7403-7407</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><coden>ACIEAY</coden><abstract>A wide range of chemical warfare agents and their simulants are catalytically decontaminated by a new one‐dimensional polymeric polyniobate (P‐PONb), K12[Ti2O2][GeNb12O40]⋅19 H2O (KGeNb) under mild conditions and in the dark. Uniquely, KGeNb facilitates hydrolysis of nerve agents Sarin (GB) and Soman (GD) (and their less reactive simulants, dimethyl methylphosphonate (DMMP)) as well as mustard (HD) in both liquid and gas phases at ambient temperature and in the absence of neutralizing bases or illumination. Three lines of evidence establish that KGeNb removes DMMP, and thus likely GB/GD, by general base catalysis: a) the k(H2O)/k(D2O) solvent isotope effect is 1.4; b) the rate law (hydrolysis at the same pH depends on the amount of P‐PONb present); and c) hydroxide is far less active against the above simulants at the same pH than the P‐PONbs themselves, a critical control experiment.
POM against CWAs: A new one‐dimensional polymeric polyniobate, K12[Ti2O2][GeNb12O40], removes a wide range of chemical warfare agents (CWAs) and their simulants. The transformations are catalytic and proceed effectively under very mild conditions and in the dark.</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>27061963</pmid><doi>10.1002/anie.201601620</doi><tpages>5</tpages><edition>International ed. in English</edition></addata></record> |
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subjects | Ambient temperature Biological & chemical weapons Catalysis Chemical warfare Chemical warfare agents Decontamination heteropolyniobates Hydrolysis Illumination Isotope effect Mustard Nerve agents Neutralizing Sarin Soman Temperature effects Vapor phases |
title | Broad-Spectrum Liquid- and Gas-Phase Decontamination of Chemical Warfare Agents by One-Dimensional Heteropolyniobates |
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