Use of atypical antipsychotics and risks of cataract development in patients with schizophrenia: A population-based, nested case-control study

Abstract Objective Previous research has suggested a link between typical antipsychotic use and the development of cataracts, but the association between atypical antipsychotics and cataracts remains unclear in schizophrenia (SZ). Methods A retrospective nested case-control study was conducted using...

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Published in:Schizophrenia research 2016-07, Vol.174 (1-3), p.137-143
Main Authors: Chou, Po-Han, Chu, Che-Sheng, Lin, Ching-Heng, Cheng, Chin, Chen, Yi-Huey, Lan, Tsuo-Hung, Huang, Min-Wei
Format: Article
Language:English
Subjects:
Antipsychotic Agents - adverse effects
Antipsychotic Agents - therapeutic use
Antipsychotics
Case-Control Studies
Cataract
Cataract - complications
Cataract - epidemiology
Comorbidity
Female
Glaucoma - complications
Glaucoma - epidemiology
Humans
Logistic Models
Male
Middle Aged
Odds Ratio
Psychiatry
Retinal Diseases - complications
Retinal Diseases - epidemiology
Retrospective Studies
Risk Factors
Schizophrenia
Schizophrenia - complications
Schizophrenia - drug therapy
Schizophrenia - epidemiology
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Summary:Abstract Objective Previous research has suggested a link between typical antipsychotic use and the development of cataracts, but the association between atypical antipsychotics and cataracts remains unclear in schizophrenia (SZ). Methods A retrospective nested case-control study was conducted using data from the National Health Insurance Database of Taiwan between the year of 2000 and 2011. A total of 2144 SZ patients with cataracts and 2222 controls matched for age, sex, and index date were included. Antipsychotic exposure was categorized by type and duration, and the association between antipsychotic exposure and cataract development was assessed using a conditional logistic regression analysis. Results We found that the severity of physical comorbidities, concurrent antidepressant use, and comorbidity with glaucoma or other retinal disorders were associated with an increased risk for cataract development. Alternatively, we did not find significant associations between continuous use of clozapine, risperidone, paliperidone, ziprasidone, olanzapine, quetiapine, amisulpride, zotepine or aripiprazole and risk of cataract development in SZ patients. Conclusions We did not detect any association between atypical antipsychotic use and risk of cataract development in SZ patients. Future studies with longitudinal ocular evaluations in patients using atypical antipsychotics are warranted to confirm our findings.
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2016.03.027