Current and Emerging Aspects of Diabetes Mellitus in Acromegaly

Diabetes mellitus is a frequent complication of acromegaly, a disease characterized by chronic hypersecretion of growth hormone (GH) by a pituitary adenoma. Diabetes occurs commonly but not only as a consequence of an insulin-resistant state induced by GH excess. The development of diabetes in patie...

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Bibliographic Details
Published in:Trends in endocrinology and metabolism 2016-07, Vol.27 (7), p.470-483
Main Authors: Frara, Stefano, Maffezzoni, Filippo, Mazziotti, Gherardo, Giustina, Andrea
Format: Article
Language:English
Subjects:
acromegaly
Acromegaly - metabolism
Animals
Cardiovascular Diseases - metabolism
cardiovascular risk
diabetes
Diabetes Mellitus - metabolism
Endocrinology & Metabolism
Growth Hormone - metabolism
Human Growth Hormone - analogs & derivatives
Human Growth Hormone - metabolism
Humans
medical therapy
pegvisomant
Pituitary Neoplasms - metabolism
Somatostatin - metabolism
somatostatin analogs
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Summary:Diabetes mellitus is a frequent complication of acromegaly, a disease characterized by chronic hypersecretion of growth hormone (GH) by a pituitary adenoma. Diabetes occurs commonly but not only as a consequence of an insulin-resistant state induced by GH excess. The development of diabetes in patients with acromegaly is clinically relevant, since such a complication is thought to increase the already elevated cardiovascular morbidity and mortality risk of the disease. Emerging data suggest that a specific cardiomyopathy can be identified in acromegaly patients with diabetes. Moreover, the presence of diabetes may also influence therapeutic decision making in acromegaly, since traditional and newly developed drugs used in this clinical setting may impact glucose metabolism regardless of control of GH hypersecretion.
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2016.04.014