Current and Emerging Aspects of Diabetes Mellitus in Acromegaly

• Published in: Trends in endocrinology and metabolism 2016-07, Vol.27 (7), p.470-483
• Main Authors: Frara, Stefano, Maffezzoni, Filippo, Mazziotti, Gherardo, Giustina, Andrea
• Format: Article
• Language: English
• Subjects: acromegaly; Acromegaly - metabolism; Animals; Cardiovascular Diseases - metabolism; cardiovascular risk; diabetes; Diabetes Mellitus - metabolism; Endocrinology & Metabolism; Growth Hormone - metabolism; Human Growth Hormone - analogs & derivatives; Human Growth Hormone - metabolism; Humans; medical therapy; pegvisomant; Pituitary Neoplasms - metabolism; Somatostatin - metabolism; somatostatin analogs
• ISSN: 1043-2760; 1879-3061
• DOI: 10.1016/j.tem.2016.04.014

Diabetes mellitus is a frequent complication of acromegaly, a disease characterized by chronic hypersecretion of growth hormone (GH) by a pituitary adenoma. Diabetes occurs commonly but not only as a consequence of an insulin-resistant state induced by GH excess. The development of diabetes in patients with acromegaly is clinically relevant, since such a complication is thought to increase the already elevated cardiovascular morbidity and mortality risk of the disease. Emerging data suggest that a specific cardiomyopathy can be identified in acromegaly patients with diabetes. Moreover, the presence of diabetes may also influence therapeutic decision making in acromegaly, since traditional and newly developed drugs used in this clinical setting may impact glucose metabolism regardless of control of GH hypersecretion.