Trends of acute kidney injury after radical or partial nephrectomy for renal cell carcinoma

Abstract Objectives To investigate the prevalence, temporal trends, and predictors of postoperative acute kidney injury (AKI) in a large cohort of patients with renal cell carcinoma treated with radical or partial nephrectomy. Methods Between January 1998 and December 2010, patients who underwent ra...

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Bibliographic Details
Published in:Urologic oncology 2016-07, Vol.34 (7), p.293.e1-293.e10
Main Authors: Schmid, Marianne, M.D, Krishna, Nandita, Ravi, Praful, M.D, Meyer, Christian P., M.D, Becker, Andreas, M.D, Dalela, Deepansh, M.D, Sood, Akshay, M.D, Chun, Felix K.-H., M.D, Kibel, Adam S., M.D, Menon, Mani, M.D, Fisch, Margit, M.D, Trinh, Quoc-Dien, M.D, Sun, Maxine, B.Sc
Format: Article
Language:English
Subjects:
Acute kidney injury
Acute Kidney Injury - epidemiology
Aged
Aged, 80 and over
Carcinoma, Renal Cell - surgery
Female
Health Care Costs
Hospital Mortality
Humans
Kidney Neoplasms - surgery
Length of Stay
Male
Middle Aged
Nationwide inpatient sample
Nephrectomy - adverse effects
Partial nephrectomy
Postoperative Complications - epidemiology
Prevalence
Prospective Studies
Radical nephrectomy
Renal cell carcinoma
Trends
Urology
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Summary:Abstract Objectives To investigate the prevalence, temporal trends, and predictors of postoperative acute kidney injury (AKI) in a large cohort of patients with renal cell carcinoma treated with radical or partial nephrectomy. Methods Between January 1998 and December 2010, patients who underwent radical or partial tumor nephrectomy were identified within the Nationwide Inpatient Sample. First, prevalence and temporal trends of AKI were analyzed. Second, predictors of AKI were identified using multivariable regression analyses. Third, associations between AKI and in-hospital complications, length of stay, hospital costs, and in-hospital mortality were evaluated using logistic regression models adjusted for clustering. Results Of total 253,046 patients, 5.5% (14,303 in radical and 3,525 in partial nephrectomy) experienced AKI. Rates of AKI significantly increased from 2.0% in 1998 to 10.4% in 2010 ( P
ISSN:1078-1439
1873-2496
DOI:10.1016/j.urolonc.2016.02.018