Stem Cells: A Renaissance in Human Biology Research

The understanding of human biology and how it relates to that of other species represents an ancient quest. Limited access to human material, particularly during early development, has restricted researchers to only scratching the surface of this inherently challenging subject. Recent technological...

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Bibliographic Details
Published in:Cell 2016-06, Vol.165 (7), p.1572-1585
Main Authors: Wu, Jun, Izpisua Belmonte, Juan Carlos
Format: Article
Language:English
Subjects:
Animals
Cytological Techniques
Embryo Implantation
Embryo, Mammalian - metabolism
Embryonic Development
Humans
Pluripotent Stem Cells - metabolism
Stem Cell Research
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Summary:The understanding of human biology and how it relates to that of other species represents an ancient quest. Limited access to human material, particularly during early development, has restricted researchers to only scratching the surface of this inherently challenging subject. Recent technological innovations, such as single cell “omics” and human stem cell derivation, have now greatly accelerated our ability to gain insights into uniquely human biology. The opportunities afforded to delve molecularly into scarce material and to model human embryogenesis and pathophysiological processes are leading to new insights of human development and are changing our understanding of disease and choice of therapy options. Advances in the culturing, analyses, and differentiation of human stem cells have afforded unprecedented insights into uniquely human biology.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2016.05.043