A Polymorphism Within the 3'UTR of NLRP3 is Associated with Susceptibility for Ischemic Stroke in Chinese Population

• Published in: Cellular and molecular neurobiology 2016-08, Vol.36 (6), p.981
• Main Authors: Zhu, Zhansheng, Yan, Jing, Geng, Chunsong, Wang, Dagang, Li, Chaoyang, Feng, Shuai, Wang, Huiping
• Format: Article
• Language: English
• Subjects: 3' Untranslated Regions - genetics; Adult; Aged; Asian People - genetics; Case-Control Studies; Female; Gene Frequency - genetics; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; NLR Family, Pyrin Domain-Containing 3 Protein - genetics; Polymorphism, Single Nucleotide - genetics; Stroke - genetics
• ISSN: 1573-6830; 1573-6830
• DOI: 10.1007/s10571-015-0288-1

Stroke was regarded as a severe disorder with high morbidity and high mortality worldwide, ischemic stroke (IS) accounts for 85 to 90 % of new increased stroke cases. Partial mechanisms were elucidated by genetic factors including genomic instability such as single nucleotide polymorphism (SNP). Previous reports demonstrated that inflammation was involved in IS, NLRP3 [nucleotide-binding domain (NOD)-like receptor protein 3], acting as a specific inflammatory gene, however, its function and influence on IS was not well clarified. In this study, a case-control study including 1102 IS patients and 1610 healthy controls was conducted to investigate the association between IS susceptibility with a SNP (rs10754558) in 3'UTR of NLRP3. Logistic regression analysis showed that the heterozygote and the homozygote GG confer a significantly increased risk of CRC after controlling for other covariates (adjusted OR = 1.52, 95 % C.I. 1.19-1.97, P = 0.002; adjusted OR = 2.22, 95 % C.I. 2.18-3.67, P