Effect of Proline-Containing Oligopeptides PGP and RGP on Proliferative and Protein-Synthesizing Activity of Cultured Pulmonary Fibroblasts under Conditions of Oxidative Stress

We studied the effect of glyprolines Pro-Gly-Pro (PGP) and Arg-Gly-Pro (RGP) on the primary culture of pulmonary fibroblasts from newborn albino rats under normal conditions and during oxidative stress. Under physiological conditions, the peptides had no effect on parameters of cell division. Hydrog...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-05, Vol.161 (1), p.184-186
Main Authors: Tolstenok, I. V., Fleishman, M. Yu, Sazonova, E. N., Lebed’ko, O. A., Maltseva, I. M., Myasoedov, N. F., Timoshin, S. S.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Blood glucose
Cell Biology
Cell Nucleolus - ultrastructure
Cell Proliferation
Cells, Cultured
DNA synthesis
Fibroblasts - drug effects
Fibroblasts - physiology
Glutamate
Glycine
Hydrogen peroxide
Internal Medicine
Laboratory Medicine
Lung - cytology
Oligopeptides
Oligopeptides - pharmacology
Oxidation-Reduction
Oxidative Stress
Pathology
Physiological aspects
Proline - analogs & derivatives
Proline - pharmacology
Protein Biosynthesis - drug effects
Rats, Wistar
Superoxides - metabolism
Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
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Summary:We studied the effect of glyprolines Pro-Gly-Pro (PGP) and Arg-Gly-Pro (RGP) on the primary culture of pulmonary fibroblasts from newborn albino rats under normal conditions and during oxidative stress. Under physiological conditions, the peptides had no effect on parameters of cell division. Hydrogen peroxide induced intensive oxidative stress accompanied by suppression of protein-synthesizing function. When hydrogen peroxide was added to the culture containing the test peptides, correction of the oxidative status was observed accompanied by activation of DNA-synthesizing activity and inhibition of lucigenin-dependent chemiluminescence.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3372-8