Ir(III)-Catalyzed Carbenoid Functionalization of Benzamides: Synthesis of N-Methoxyisoquinolinediones and N-Methoxyisoquinolinones

A mild and efficient Ir(III)-catalyzed C-H carbenoid functionalization strategy has been developed to access N-methoxyisoquinolinediones and N-methoxyisoquinolinones. The reaction proceeds efficiently in high yield at room temperature over a broad range of substrates without requirement of any addit...

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Bibliographic Details
Published in:Organic letters 2016-06, Vol.18 (12), p.2828-2831
Main Authors: Phatake, Ravindra S, Patel, Pitambar, Ramana, Chepuri V
Format: Article
Language:English
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Summary:A mild and efficient Ir(III)-catalyzed C-H carbenoid functionalization strategy has been developed to access N-methoxyisoquinolinediones and N-methoxyisoquinolinones. The reaction proceeds efficiently in high yield at room temperature over a broad range of substrates without requirement of any additional oxidants or a base.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.6b01072