Quantitative Assessment of Bone Marrow Cellularity by Magnetic Resonance Imaging in Workers with Long-Term Exposure to Solvents

This study was conducted to develop a noninvasive method of bone marrow cellularity evaluation in solvent-exposed painters. Six painters with hypocellular marrow and 132 referents were examined using magnetic resonance imaging (MRI). Full examination of the peripheral blood and bone marrow biopsy wa...

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Bibliographic Details
Published in:Industrial Health 2004, Vol.42(2), pp.179-188
Main Authors: CHEONG, Hae-Kwan, CHOI, Dae Seob, PARK, Keon Uk, KIM, Jung Ran, HA, Kyung-Im, YUN, Hwan Jung, YANG, Seoung-Oh, KIM, Yangho
Format: Article
Language:English
Subjects:
Adult
Bone Marrow Cells - pathology
Bone marrow disorders
Bone Marrow Examination
Female
Humans
Leukopenia
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Middle Aged
Occupational Diseases - blood
Occupational Diseases - chemically induced
Occupational Diseases - diagnosis
Occupational exposure
Occupational Exposure - adverse effects
Occupational Exposure - analysis
Reference Values
Solvents
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Summary:This study was conducted to develop a noninvasive method of bone marrow cellularity evaluation in solvent-exposed painters. Six painters with hypocellular marrow and 132 referents were examined using magnetic resonance imaging (MRI). Full examination of the peripheral blood and bone marrow biopsy was done on each patient. Signal indices were calculated from the signal intensities measured at the vertebral bodies from T12 to S1 and on the paraspinal muscles on both the T1- and the T2-weighted image (T1WI and T2WI). Bone marrow cellularities of the painters were between 20.3% and 33.6%. Signal indices at T1WI were greater in the hypocellular marrow cases compared to those of the referents (p
ISSN:0019-8366
1880-8026
DOI:10.2486/indhealth.42.179