Effects of propolis in an experimental rat model of allergic rhinitis

Abstract Purpose The aim of this study was to determine the anti-allergic activity of propolis in an ovalbumin-induced rat model of allergic rhinitis. Materials and methods This prospective experimental study was conducted at Hakan Çetinsaya Clinical and Experimental Animal Research Center with 30 r...

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Published in:American journal of otolaryngology 2016-07, Vol.37 (4), p.287-293
Main Authors: Yasar, Mehmet, MD, Savranlar, Yasemin, MD, Karaman, Hatice, MD, Sagit, Mustafa, Silici, Sibel, Ozcan, Ibrahim
Format: Article
Language:English
Subjects:
Allergies
Animals
Anti-Infective Agents - therapeutic use
Disease Models, Animal
Ethanol
Histology
Inflammation
Male
Nose
Otolaryngology
Ovalbumin
Propolis - therapeutic use
Rats
Rats, Sprague-Dawley
Rhinitis, Allergic - drug therapy
Rhinitis, Allergic - etiology
Rhinitis, Allergic - pathology
Rodents
Studies
Surgery
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Summary:Abstract Purpose The aim of this study was to determine the anti-allergic activity of propolis in an ovalbumin-induced rat model of allergic rhinitis. Materials and methods This prospective experimental study was conducted at Hakan Çetinsaya Clinical and Experimental Animal Research Center with 30 rats. After sensitization of all rats with 0.3 mg intraperitoneal ovalbumin plus 30 mg aluminum hydroxide for 14 day (first phase), rats were divided to five groups. In the second phase of the study 10 μL of ovalbumin was applied to each nostril for 21 days. Together with second phase, ketotifen (n:6), oral propolis (n:6), intranasal propolis (n:6) and intranasal mometasone furoate (n:6) was given to rats. A control group (n:4)(salin) and sham group (n:2) was planned. Symptoms were assessed on days 19, 22, 25, 30 and 35, resulting in 5 symptom scores: symptom scores 1–5. On day 35, nasal tissue were removed and histological examination was performed. Results When rats that received systemic and intranasal propolis were compared to controls, ciliary loss, inflammation, increase in goblet cells, vascular proliferation, eosinophil count, chondrocytes and allergic rhinitis symptom score were found to be decreased (p < 0.05). Conclusions It was found that propolis had anti-allergic effects on allergic symptom scores and nasal histology.
ISSN:0196-0709
1532-818X
DOI:10.1016/j.amjoto.2016.03.007