Temporary impairment of reproduction in freshwater teleost exposed to nonylphenol

New born guppies, Poecilia reticulata, were exposed to a sublethal concentration of nonylphenol (NP) for 90 days, with the aim of evaluating the influence that this pollutant has on reproductive functions. At the end of treatment, the gender balance was significantly biased towards females ( sex rat...

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Bibliographic Details
Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2004-06, Vol.18 (4), p.597-604
Main Authors: Cardinali, Marco, Maradonna, Francesca, Olivotto, Ike, Bortoluzzi, Guido, Mosconi, Gilberto, Polzonetti-Magni, Alberta M, Carnevali, Oliana
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Base Sequence
Biological and medical sciences
Blotting, Southern
Cloning, Molecular
Embryology: invertebrates and vertebrates. Teratology
Endocrine disrupters
Female
Fish
Fundamental and applied biological sciences. Psychology
Fundulidae
Gene Expression Regulation - drug effects
Gonads - anatomy & histology
Gonads - drug effects
Male
Medical sciences
Molecular Sequence Data
Nonylphenol
Phenols - toxicity
Poecilia - physiology
Poecilia reticulata
Pollution
Reproduction - drug effects
Reproductive impairment
Reverse Transcriptase Polymerase Chain Reaction
RNA - biosynthesis
Sex behavior
Sex Differentiation - drug effects
Sex Ratio
Sexual Behavior, Animal - drug effects
Teratology. Teratogens
Toxicology
Vitellogenin
Vitellogenins - biosynthesis
Vitellogenins - genetics
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Summary:New born guppies, Poecilia reticulata, were exposed to a sublethal concentration of nonylphenol (NP) for 90 days, with the aim of evaluating the influence that this pollutant has on reproductive functions. At the end of treatment, the gender balance was significantly biased towards females ( sex ratio =0.3 males per female). Treated males displayed anomalous transcription of vitellogenin in correlation with a significant reduction of the gonadosomatic index (GSI); however, an increase of vitellogenin gene transcription, correlating directly with an increase in GSI, was observed in NP treated females. The hepatosomatic index (HSI) was significantly increased in exposed males and females. Females exposed to NP showed no alteration of sexual behavior or reproduction. These findings in guppies suggest that NP has estrogenic potency sufficient to disturb reproduction. Effects were transitory in nature because three months in uncontaminated water allowed males to recover normal sexual efficiency.
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2004.03.001