Hyalinizing Clear Cell Carcinoma with Biopsy-Proven Spinal Metastasis: Case Report and Review of Literature

Background Hyalinizing clear cell carcinoma (HCCC) is a rare epithelial malignant neoplasm typically arising from the minor salivary glands. Although it has been described as a benign neoplasm, there are increasing reports of malignant features and metastases to the lungs; we present the first case...

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Bibliographic Details
Published in:World neurosurgery 2016-06, Vol.90, p.699.e7-699.e10
Main Authors: Newman, William C, Williams, Lindsay, Duvvuri, Umamaheswar, Clump, David A, Amankulor, Nduka
Format: Article
Language:English
Subjects:
Aged
Diagnosis, Differential
EWSR1-ATF1
Female
Fluorescence in situ hybridization
Genetic Testing
Histopathology
Humans
Hyalinizing clear cell carcinoma
Neurosurgery
Salivary Gland Neoplasms - genetics
Salivary Gland Neoplasms - pathology
Sarcoma, Clear Cell - genetics
Sarcoma, Clear Cell - pathology
Sarcoma, Clear Cell - secondary
Spinal Neoplasms - genetics
Spinal Neoplasms - pathology
Spinal Neoplasms - secondary
Spine metastasis
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Summary:Background Hyalinizing clear cell carcinoma (HCCC) is a rare epithelial malignant neoplasm typically arising from the minor salivary glands. Although it has been described as a benign neoplasm, there are increasing reports of malignant features and metastases to the lungs; we present the first case of biopsy-proven spinal metastases from HCCC and an overview of the literature. Case Description This is a single-patient case report in which we used immunohistochemistry and fluorescence in situ hybridization for Ewing sarcoma breakpoint region 1 translocation to confirm the diagnosis of HCCC in a spinal metastasis. The diagnosis of metastatic HCCC was confirmed on the basis of histopathology, immunohistochemistry, and fluorescence in situ hybridization studies. Conclusions We present the first pathologically confirmed case of a spinal metastasis in HCCC. As increasing of metastatic HCCC arise, a reconsideration of HCCC as a potentially high-grade disease seems increasingly necessary as it may impact the current treatment paradigm.
ISSN:1878-8750
1878-8769
DOI:10.1016/j.wneu.2016.02.001