The Predictive Role of Serum Cystatin C Levels in Polycystic Ovary Syndrome in Adolescents

Abstract Study Objective To evaluate the correlation between serum cystatin levels and clinical parameters in adolescents with polycystic ovary syndrome (PCOS). Design, Setting, Participants, Interventions, and Main Outcome Measures This prospective case-control study included 89 adolescents with PC...

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Bibliographic Details
Published in:Journal of pediatric & adolescent gynecology 2016-08, Vol.29 (4), p.353-356
Main Authors: Çınar, Mehmet, MD, Aksoy, Rıfat Taner, MD, Güzel, Ali İrfan, MD, Tokmak, Aytekin, MD, Çandar, Tuğba, MD, Taşçı, Yasemin, MD
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomarkers - blood
Body Mass Index
C-Reactive Protein - analysis
Case-Control Studies
Cholesterol - blood
Cystatin C - blood
Cystatin C levels
Estradiol - blood
Etiology
Female
Follicle Stimulating Hormone - blood
Humans
Inflammation
Insulin - blood
Insulin Resistance
Luteinizing Hormone - blood
Obstetrics and Gynecology
Pediatrics
Polycystic ovary syndrome
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - diagnosis
Predictive Value of Tests
Prospective Studies
Risk Factors
Testosterone - blood
Triglycerides - blood
Waist-Hip Ratio
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Summary:Abstract Study Objective To evaluate the correlation between serum cystatin levels and clinical parameters in adolescents with polycystic ovary syndrome (PCOS). Design, Setting, Participants, Interventions, and Main Outcome Measures This prospective case-control study included 89 adolescents with PCOS. Demographic characteristics and hormonal and biochemical parameters were compared between study (89 patients with PCOS) and control (84 subjects without PCOS) groups. Risk factors recorded were age, body mass index (BMI), waist to hip ratio (WHR), Ferriman–Gallwey score, triglyceride, total cholesterol, high-density lipoprotein, low-density lipoprotein (LDL), high-sensitivity C-reactive protein, cystatin C, follicle stimulating hormone, luteinizing hormone, estradiol, dehydroepiandrosterone sulfate, homeostatic model assessment insulin resistance index, free testosterone, and progesterone levels. Results BMI, WHR, Ferriman–Gallwey score, and triglyceride, LDL, total cholesterol, estradiol, dehydroepiandrosterone sulfate, free testosterone, luteinizing hormone, high-sensitivity C-reactive protein, and cystatin C levels, and homeostatic model assessment insulin resistance index scores were significantly higher, and high-density lipoprotein levels were lower in the PCOS patients compared with healthy subjects ( P  
ISSN:1083-3188
1873-4332
DOI:10.1016/j.jpag.2015.12.005