Soluble Urokinase Plasminogen Activator Receptor: A New Biomarker in the Pediatric Intensive Care Unit

Objective To evaluate the value of soluble urokinase plasminogen activator receptor (suPAR) in diagnosing sepsis and predicting mortality in critically ill children. Methods In a prospective cohort study, 69 critically ill children admitted into the pediatric intensive care unit (PICU) were randomly...

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Bibliographic Details
Published in:Indian journal of pediatrics 2016-07, Vol.83 (7), p.661-669
Main Authors: El-Mekkawy, Muhammad S., Saleh, Nagwan Y., Sonbol, Ahmed A.
Format: Article
Language:English
Subjects:
Biomarkers
C-Reactive Protein - analysis
Child
Critical Illness
Gynecology
Humans
Intensive Care Units, Pediatric
Medicine
Medicine & Public Health
Original Article
Pediatrics
Prognosis
Prospective Studies
Receptors, Urokinase Plasminogen Activator - blood
ROC Curve
Sepsis - diagnosis
Sepsis - mortality
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Summary:Objective To evaluate the value of soluble urokinase plasminogen activator receptor (suPAR) in diagnosing sepsis and predicting mortality in critically ill children. Methods In a prospective cohort study, 69 critically ill children admitted into the pediatric intensive care unit (PICU) were randomly enrolled in addition to 15 healthy children as a control group. Clinical examination was performed, including calculation of the Pediatric Risk of Mortality (PRISM) and Pediatric Index of Mortality2 (PIM2). suPAR was measured in patients at admission as well as in the controls. Patients were followed up for 30 d. Results suPAR level was significantly higher among the total patient cohort compared to controls ( p  
ISSN:0019-5456
0973-7693
DOI:10.1007/s12098-016-2063-9