Umbilical arterial N-terminal pro-B-type natriuretic peptide levels in preeclampsia, fetal growth restriction, preterm birth and fetal distress

To evaluate fetal cardiopulmonary stress in pregnancies complicated by preeclampsia (PE), fetal growth restriction (FGR), preterm birth (PT), and fetal distress (FD) using umbilical arterial blood N-terminal pro-B-type natriuretic peptide (NT-proBNP). The study included 146 blood samples that were d...

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Bibliographic Details
Published in:Clinical and experimental obstetrics & gynecology 2016-01, Vol.43 (3), p.393-396
Main Authors: Bae, J Y, Seong, W J
Format: Article
Language:English
Subjects:
Adult
Biomarkers
Birth Weight
Female
Fetal Blood
Fetal Distress - blood
Fetal Growth Retardation - blood
Gestational Age
Humans
Infant, Newborn
Natriuretic Peptide, Brain - blood
Peptide Fragments - blood
Pre-Eclampsia - blood
Pregnancy
Premature Birth - blood
Prospective Studies
Umbilical Arteries
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Summary:To evaluate fetal cardiopulmonary stress in pregnancies complicated by preeclampsia (PE), fetal growth restriction (FGR), preterm birth (PT), and fetal distress (FD) using umbilical arterial blood N-terminal pro-B-type natriuretic peptide (NT-proBNP). The study included 146 blood samples that were drawn from umbilical arteries at the time of delivery (20 cases of PE, 11 cases of FGR, 31 cases of PT, 23 cases of FD, and 61 cases of gestational age-matched controls) and analyzed. The main outcome measures included neonatal birthweight, cord pH, and umbilical arterial NT-proBNP. The umbilical arterial NT-proBNP levels were significantly higher in the PE, FGR, PT, and FD groups than in the control group. The umbilical arterial NT-proBNP levels were negatively correlated with gestational age, birthweight, and umbilical arterial pH. Umbilical arterial NT-proBNP levels are elevated in stressful fetal conditions and have the potential to be considered as a marker for fetal cardiopulmonary stress.
ISSN:0390-6663
DOI:10.12891/ceog3103.2016