Pharmacogenomics of multifactorial diseases: a focus on psoriatic arthritis

This review will outline the current pharmacogenomics knowledge about psoriatic arthritis with a special attention to the perspectives and the challenges for its implementation in the clinical practice. To date, different drugs have been developed to contrast the symptoms and the progression of psor...

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Bibliographic Details
Published in:Pharmacogenomics 2016-06, Vol.17 (8), p.943-951
Main Authors: Cascella, Raffaella, Strafella, Claudia, Longo, Giuliana, Maccarone, Mara, Borgiani, Paola, Sangiuolo, Federica, Novelli, Giuseppe, Giardina, Emiliano
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Arthritis
Arthritis, Psoriatic - drug therapy
Arthritis, Psoriatic - genetics
Arthritis, Psoriatic - psychology
Cell growth
Clinical medicine
Drug development
Drug dosages
Enzymes
Genes
Genomes
healthcare approach
Humans
Inflammation
Patients
Pharmacogenetics
Pharmacogenomics
Precision medicine
precision/personalized medicine
Psoriasis
Psoriatic arthritis
Quality of Life
Tumor Necrosis Factor-alpha - antagonists & inhibitors
Tumor necrosis factor-TNF
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Summary:This review will outline the current pharmacogenomics knowledge about psoriatic arthritis with a special attention to the perspectives and the challenges for its implementation in the clinical practice. To date, different drugs have been developed to contrast the symptoms and the progression of psoriatic arthritis. However, patients have shown high variability of drug response in relation to their genetic makeup. In this context, the advances made in the knowledge and the potentialities of genome-drugs associations paved the path for the development of a precision medicine. In fact, these associations may be successfully combined with the environment information to provide new strategies able to prevent and improve the disease management as well as to enhance the patients quality of life.
ISSN:1462-2416
1744-8042
DOI:10.2217/pgs.16.20