Loading…
Left ventricular diastolic dysfunction is associated with atrial remodeling and risk or presence of stroke in patients with paroxysmal atrial fibrillation
Abstract Background Although the degree of electroanatomical remodeling of the left atrium (LA) is influenced by left ventricular (LV) diastolic function, clinical implications of estimated LV filling pressure (E/Em) are limited in patients with atrial fibrillation (AF). We hypothesized that increas...
Saved in:
| Published in: | Journal of cardiology 2016-08, Vol.68 (2), p.104-109 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c479t-e82da603db99a7fdb74f6e771b35542ae316456f1bf85304344f424363ff80a53 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c479t-e82da603db99a7fdb74f6e771b35542ae316456f1bf85304344f424363ff80a53 |
| container_end_page | 109 |
| container_issue | 2 |
| container_start_page | 104 |
| container_title | Journal of cardiology |
| container_volume | 68 |
| creator | Kim, Tae-Hoon, MD Shim, Chi Young, MD, PhD Park, Jae Hyung, PhD Nam, Chung Mo, PhD Uhm, Jae-Sun, MD Joung, Boyoung, MD, PhD Lee, Moon-Hyoung, MD, PhD Pak, Hui-Nam, MD, PhD |
| description | Abstract Background Although the degree of electroanatomical remodeling of the left atrium (LA) is influenced by left ventricular (LV) diastolic function, clinical implications of estimated LV filling pressure (E/Em) are limited in patients with atrial fibrillation (AF). We hypothesized that increased E/Em is related to an advanced LA remodeling, a high CHA2 DS2 -VASc score, and the presence of stroke or transient ischemic attack (TIA) in patients with paroxysmal AF. Methods We included 1098 patients with paroxysmal AF (male 74.5%, 57.6 ± 11.3 years old) who underwent AF catheter ablation. We compared E/Em to clinical parameters, echocardiography, and three-dimensional-computed tomography findings. Results The E/Em > 15 group ( n = 98) was older ( p < 0.001) and had more females ( p < 0.001), greater LA volume index ( p < 0.001), higher CHA2 DS2 -VASc score ( p < 0.001), and stroke/TIA prevalence ( p = 0.001) than groups with an E/Em of 8–15 ( n = 676) or |
| doi_str_mv | 10.1016/j.jjcc.2015.10.008 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1800130327</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0914508715003342</els_id><sourcerecordid>1800130327</sourcerecordid><originalsourceid>FETCH-LOGICAL-c479t-e82da603db99a7fdb74f6e771b35542ae316456f1bf85304344f424363ff80a53</originalsourceid><addsrcrecordid>eNp9krGO1DAQhiME4vYOXoACuaTJYsdO4kgICZ3gQFqJAqgtxx6Ds0kcPM7BvgpPi6NdKCioLI3-_xvP_FMUzxjdM8qal8N-GIzZV5TVubCnVD4odky2TSlaLh8WO9oxUdZUtlfFNeJAaUM72TwurqqmoZxXclf8OoBL5B7mFL1ZRx2J9RpTGL0h9oRunU3yYSYeiUYMxusElvzw6RvR2aJHEmEKFkY_fyV6tiR6PJIQyRIBYTZAgiOYYjgC8TNZdPK5F54Ji47h5wmnTLnAnO-jH0e99XxSPHJ6RHh6eW-KL-_efr59Xx4-3n24fXMojWi7VIKsrM7j2L7rdOts3wrXQNuynte1qDRw1oi6cax3suZUcCGcqARvuHOS6prfFC_O3CWG7ytgUpNHA_kXM4QVFZOUMk551WZpdZaaGBAjOLVEP-l4UoyqLRM1qC0TtWWy1XIm2fT8wl_7Cexfy58QsuDVWQB5ynsPUaHx2-6sj2CSssH_n__6H7vJaXijxyOcAIewxjnvTzGFlaLq03YV21Gwmub-ouK_AROjtco</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1800130327</pqid></control><display><type>article</type><title>Left ventricular diastolic dysfunction is associated with atrial remodeling and risk or presence of stroke in patients with paroxysmal atrial fibrillation</title><source>Elsevier</source><creator>Kim, Tae-Hoon, MD ; Shim, Chi Young, MD, PhD ; Park, Jae Hyung, PhD ; Nam, Chung Mo, PhD ; Uhm, Jae-Sun, MD ; Joung, Boyoung, MD, PhD ; Lee, Moon-Hyoung, MD, PhD ; Pak, Hui-Nam, MD, PhD</creator><creatorcontrib>Kim, Tae-Hoon, MD ; Shim, Chi Young, MD, PhD ; Park, Jae Hyung, PhD ; Nam, Chung Mo, PhD ; Uhm, Jae-Sun, MD ; Joung, Boyoung, MD, PhD ; Lee, Moon-Hyoung, MD, PhD ; Pak, Hui-Nam, MD, PhD</creatorcontrib><description>Abstract Background Although the degree of electroanatomical remodeling of the left atrium (LA) is influenced by left ventricular (LV) diastolic function, clinical implications of estimated LV filling pressure (E/Em) are limited in patients with atrial fibrillation (AF). We hypothesized that increased E/Em is related to an advanced LA remodeling, a high CHA2 DS2 -VASc score, and the presence of stroke or transient ischemic attack (TIA) in patients with paroxysmal AF. Methods We included 1098 patients with paroxysmal AF (male 74.5%, 57.6 ± 11.3 years old) who underwent AF catheter ablation. We compared E/Em to clinical parameters, echocardiography, and three-dimensional-computed tomography findings. Results The E/Em > 15 group ( n = 98) was older ( p < 0.001) and had more females ( p < 0.001), greater LA volume index ( p < 0.001), higher CHA2 DS2 -VASc score ( p < 0.001), and stroke/TIA prevalence ( p = 0.001) than groups with an E/Em of 8–15 ( n = 676) or <8 ( n = 324). An E/Em was independently associated with the presence of stroke/TIA (OR 1.638, 95% CI 1.050–2.554, p = 0.030) after adjusting for age, sex, body surface area, LA volume index, and LA appendage volume index. Conclusions In patients with paroxysmal AF, the elevated LV filling pressure estimated by E/Em is independently associated with the presence of stroke or TIA.</description><identifier>ISSN: 0914-5087</identifier><identifier>EISSN: 1876-4738</identifier><identifier>DOI: 10.1016/j.jjcc.2015.10.008</identifier><identifier>PMID: 26603328</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Age Factors ; Aged ; Atrial Appendage - physiopathology ; Atrial fibrillation ; Atrial Fibrillation - complications ; Atrial Fibrillation - physiopathology ; Atrial Fibrillation - surgery ; Atrial Remodeling ; Cardiovascular ; Catheter ablation ; Catheter Ablation - methods ; Echocardiography ; Female ; Heart Atria - physiopathology ; Humans ; Ischemic Attack, Transient - etiology ; Left ventricular filling pressure ; Male ; Middle Aged ; Risk Factors ; Sex Factors ; Stroke ; Stroke - etiology ; Stroke Volume ; Tomography, X-Ray Computed ; Ventricular Dysfunction, Left - complications ; Ventricular Dysfunction, Left - physiopathology ; Ventricular Function, Left</subject><ispartof>Journal of cardiology, 2016-08, Vol.68 (2), p.104-109</ispartof><rights>Japanese College of Cardiology</rights><rights>2015 Japanese College of Cardiology</rights><rights>Copyright © 2015 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-e82da603db99a7fdb74f6e771b35542ae316456f1bf85304344f424363ff80a53</citedby><cites>FETCH-LOGICAL-c479t-e82da603db99a7fdb74f6e771b35542ae316456f1bf85304344f424363ff80a53</cites><orcidid>0000-0002-3256-3620</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26603328$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Tae-Hoon, MD</creatorcontrib><creatorcontrib>Shim, Chi Young, MD, PhD</creatorcontrib><creatorcontrib>Park, Jae Hyung, PhD</creatorcontrib><creatorcontrib>Nam, Chung Mo, PhD</creatorcontrib><creatorcontrib>Uhm, Jae-Sun, MD</creatorcontrib><creatorcontrib>Joung, Boyoung, MD, PhD</creatorcontrib><creatorcontrib>Lee, Moon-Hyoung, MD, PhD</creatorcontrib><creatorcontrib>Pak, Hui-Nam, MD, PhD</creatorcontrib><title>Left ventricular diastolic dysfunction is associated with atrial remodeling and risk or presence of stroke in patients with paroxysmal atrial fibrillation</title><title>Journal of cardiology</title><addtitle>J Cardiol</addtitle><description>Abstract Background Although the degree of electroanatomical remodeling of the left atrium (LA) is influenced by left ventricular (LV) diastolic function, clinical implications of estimated LV filling pressure (E/Em) are limited in patients with atrial fibrillation (AF). We hypothesized that increased E/Em is related to an advanced LA remodeling, a high CHA2 DS2 -VASc score, and the presence of stroke or transient ischemic attack (TIA) in patients with paroxysmal AF. Methods We included 1098 patients with paroxysmal AF (male 74.5%, 57.6 ± 11.3 years old) who underwent AF catheter ablation. We compared E/Em to clinical parameters, echocardiography, and three-dimensional-computed tomography findings. Results The E/Em > 15 group ( n = 98) was older ( p < 0.001) and had more females ( p < 0.001), greater LA volume index ( p < 0.001), higher CHA2 DS2 -VASc score ( p < 0.001), and stroke/TIA prevalence ( p = 0.001) than groups with an E/Em of 8–15 ( n = 676) or <8 ( n = 324). An E/Em was independently associated with the presence of stroke/TIA (OR 1.638, 95% CI 1.050–2.554, p = 0.030) after adjusting for age, sex, body surface area, LA volume index, and LA appendage volume index. Conclusions In patients with paroxysmal AF, the elevated LV filling pressure estimated by E/Em is independently associated with the presence of stroke or TIA.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Atrial Appendage - physiopathology</subject><subject>Atrial fibrillation</subject><subject>Atrial Fibrillation - complications</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Atrial Fibrillation - surgery</subject><subject>Atrial Remodeling</subject><subject>Cardiovascular</subject><subject>Catheter ablation</subject><subject>Catheter Ablation - methods</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Heart Atria - physiopathology</subject><subject>Humans</subject><subject>Ischemic Attack, Transient - etiology</subject><subject>Left ventricular filling pressure</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Stroke</subject><subject>Stroke - etiology</subject><subject>Stroke Volume</subject><subject>Tomography, X-Ray Computed</subject><subject>Ventricular Dysfunction, Left - complications</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><subject>Ventricular Function, Left</subject><issn>0914-5087</issn><issn>1876-4738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp9krGO1DAQhiME4vYOXoACuaTJYsdO4kgICZ3gQFqJAqgtxx6Ds0kcPM7BvgpPi6NdKCioLI3-_xvP_FMUzxjdM8qal8N-GIzZV5TVubCnVD4odky2TSlaLh8WO9oxUdZUtlfFNeJAaUM72TwurqqmoZxXclf8OoBL5B7mFL1ZRx2J9RpTGL0h9oRunU3yYSYeiUYMxusElvzw6RvR2aJHEmEKFkY_fyV6tiR6PJIQyRIBYTZAgiOYYjgC8TNZdPK5F54Ji47h5wmnTLnAnO-jH0e99XxSPHJ6RHh6eW-KL-_efr59Xx4-3n24fXMojWi7VIKsrM7j2L7rdOts3wrXQNuynte1qDRw1oi6cax3suZUcCGcqARvuHOS6prfFC_O3CWG7ytgUpNHA_kXM4QVFZOUMk551WZpdZaaGBAjOLVEP-l4UoyqLRM1qC0TtWWy1XIm2fT8wl_7Cexfy58QsuDVWQB5ynsPUaHx2-6sj2CSssH_n__6H7vJaXijxyOcAIewxjnvTzGFlaLq03YV21Gwmub-ouK_AROjtco</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Kim, Tae-Hoon, MD</creator><creator>Shim, Chi Young, MD, PhD</creator><creator>Park, Jae Hyung, PhD</creator><creator>Nam, Chung Mo, PhD</creator><creator>Uhm, Jae-Sun, MD</creator><creator>Joung, Boyoung, MD, PhD</creator><creator>Lee, Moon-Hyoung, MD, PhD</creator><creator>Pak, Hui-Nam, MD, PhD</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3256-3620</orcidid></search><sort><creationdate>20160801</creationdate><title>Left ventricular diastolic dysfunction is associated with atrial remodeling and risk or presence of stroke in patients with paroxysmal atrial fibrillation</title><author>Kim, Tae-Hoon, MD ; Shim, Chi Young, MD, PhD ; Park, Jae Hyung, PhD ; Nam, Chung Mo, PhD ; Uhm, Jae-Sun, MD ; Joung, Boyoung, MD, PhD ; Lee, Moon-Hyoung, MD, PhD ; Pak, Hui-Nam, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-e82da603db99a7fdb74f6e771b35542ae316456f1bf85304344f424363ff80a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Atrial Appendage - physiopathology</topic><topic>Atrial fibrillation</topic><topic>Atrial Fibrillation - complications</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Atrial Fibrillation - surgery</topic><topic>Atrial Remodeling</topic><topic>Cardiovascular</topic><topic>Catheter ablation</topic><topic>Catheter Ablation - methods</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Heart Atria - physiopathology</topic><topic>Humans</topic><topic>Ischemic Attack, Transient - etiology</topic><topic>Left ventricular filling pressure</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Stroke</topic><topic>Stroke - etiology</topic><topic>Stroke Volume</topic><topic>Tomography, X-Ray Computed</topic><topic>Ventricular Dysfunction, Left - complications</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Tae-Hoon, MD</creatorcontrib><creatorcontrib>Shim, Chi Young, MD, PhD</creatorcontrib><creatorcontrib>Park, Jae Hyung, PhD</creatorcontrib><creatorcontrib>Nam, Chung Mo, PhD</creatorcontrib><creatorcontrib>Uhm, Jae-Sun, MD</creatorcontrib><creatorcontrib>Joung, Boyoung, MD, PhD</creatorcontrib><creatorcontrib>Lee, Moon-Hyoung, MD, PhD</creatorcontrib><creatorcontrib>Pak, Hui-Nam, MD, PhD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Tae-Hoon, MD</au><au>Shim, Chi Young, MD, PhD</au><au>Park, Jae Hyung, PhD</au><au>Nam, Chung Mo, PhD</au><au>Uhm, Jae-Sun, MD</au><au>Joung, Boyoung, MD, PhD</au><au>Lee, Moon-Hyoung, MD, PhD</au><au>Pak, Hui-Nam, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Left ventricular diastolic dysfunction is associated with atrial remodeling and risk or presence of stroke in patients with paroxysmal atrial fibrillation</atitle><jtitle>Journal of cardiology</jtitle><addtitle>J Cardiol</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>68</volume><issue>2</issue><spage>104</spage><epage>109</epage><pages>104-109</pages><issn>0914-5087</issn><eissn>1876-4738</eissn><abstract>Abstract Background Although the degree of electroanatomical remodeling of the left atrium (LA) is influenced by left ventricular (LV) diastolic function, clinical implications of estimated LV filling pressure (E/Em) are limited in patients with atrial fibrillation (AF). We hypothesized that increased E/Em is related to an advanced LA remodeling, a high CHA2 DS2 -VASc score, and the presence of stroke or transient ischemic attack (TIA) in patients with paroxysmal AF. Methods We included 1098 patients with paroxysmal AF (male 74.5%, 57.6 ± 11.3 years old) who underwent AF catheter ablation. We compared E/Em to clinical parameters, echocardiography, and three-dimensional-computed tomography findings. Results The E/Em > 15 group ( n = 98) was older ( p < 0.001) and had more females ( p < 0.001), greater LA volume index ( p < 0.001), higher CHA2 DS2 -VASc score ( p < 0.001), and stroke/TIA prevalence ( p = 0.001) than groups with an E/Em of 8–15 ( n = 676) or <8 ( n = 324). An E/Em was independently associated with the presence of stroke/TIA (OR 1.638, 95% CI 1.050–2.554, p = 0.030) after adjusting for age, sex, body surface area, LA volume index, and LA appendage volume index. Conclusions In patients with paroxysmal AF, the elevated LV filling pressure estimated by E/Em is independently associated with the presence of stroke or TIA.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>26603328</pmid><doi>10.1016/j.jjcc.2015.10.008</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-3256-3620</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0914-5087 |
| ispartof | Journal of cardiology, 2016-08, Vol.68 (2), p.104-109 |
| issn | 0914-5087 1876-4738 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1800130327 |
| source | Elsevier |
| subjects | Age Factors Aged Atrial Appendage - physiopathology Atrial fibrillation Atrial Fibrillation - complications Atrial Fibrillation - physiopathology Atrial Fibrillation - surgery Atrial Remodeling Cardiovascular Catheter ablation Catheter Ablation - methods Echocardiography Female Heart Atria - physiopathology Humans Ischemic Attack, Transient - etiology Left ventricular filling pressure Male Middle Aged Risk Factors Sex Factors Stroke Stroke - etiology Stroke Volume Tomography, X-Ray Computed Ventricular Dysfunction, Left - complications Ventricular Dysfunction, Left - physiopathology Ventricular Function, Left |
| title | Left ventricular diastolic dysfunction is associated with atrial remodeling and risk or presence of stroke in patients with paroxysmal atrial fibrillation |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T19%3A46%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Left%20ventricular%20diastolic%20dysfunction%20is%20associated%20with%20atrial%20remodeling%20and%20risk%20or%20presence%20of%20stroke%20in%20patients%20with%20paroxysmal%20atrial%20fibrillation&rft.jtitle=Journal%20of%20cardiology&rft.au=Kim,%20Tae-Hoon,%20MD&rft.date=2016-08-01&rft.volume=68&rft.issue=2&rft.spage=104&rft.epage=109&rft.pages=104-109&rft.issn=0914-5087&rft.eissn=1876-4738&rft_id=info:doi/10.1016/j.jjcc.2015.10.008&rft_dat=%3Cproquest_cross%3E1800130327%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c479t-e82da603db99a7fdb74f6e771b35542ae316456f1bf85304344f424363ff80a53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1800130327&rft_id=info:pmid/26603328&rfr_iscdi=true |