Investigation of Vasodilatory Substances in Diesel Exhaust Particles (DEP): Isolation and Identification of Nitrophenol Derivatives

Vasodilatory compounds in the weak acidic fraction of a benzene extract of diesel exhaust particles (DEP) were fractionated by column chromatography through silica gel, and the chemical structures of these compounds were analyzed using GC-MS and 1H-NMR. The compounds in DEP that cause vasodilation —...

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Bibliographic Details
Published in:Journal of Health Science 2004, Vol.50(2), pp.133-141
Main Authors: Shinji, Taneda, Kazuyuki, Kamata, Hideyuki, Hayashi, Noriko, Toda, Koh-ichi, Seki, Akiyo, Sakushima, Shin, Yoshino, Kouya, Yamaki, Masakatsu, Sakata, Yoki, Mori, K., Suzuki Akira
Format: Article
Language:English
Subjects:
diesel exhaust particles
nitrophenols
vasodilation
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Summary:Vasodilatory compounds in the weak acidic fraction of a benzene extract of diesel exhaust particles (DEP) were fractionated by column chromatography through silica gel, and the chemical structures of these compounds were analyzed using GC-MS and 1H-NMR. The compounds in DEP that cause vasodilation — 3- and 4-nitrophenol, 2-methyl-4-nitrophenol, 3-methy-4-nitrophenol, and 4-nitro-3-phenylphenol — were isolated and identified. All five of these nitrophenols had vasodilatory activities (10-4 to 10-6 M) in rat thoracic artery assays, and 4-nitro-3-phenylphenol was the most potent vasodilator among these compounds. In addition, nine other alkylnitrophenols were isolated from the benzene extract of DEP and characterized.
ISSN:1344-9702
1347-5207
DOI:10.1248/jhs.50.133