Determination of Acetaminophen Residues in Whole Body Brown Treesnakes

Acetaminophen was extracted from brown treesnakes (Boiga irregularis) and analyzed by reversed-phase high-performance liquid chromatography (HPLC). Acetaminophen was quantified by UV absorbance at 250 nm. Recoveries were determined by analyzing acetaminophen-fortified blank homogenized tissue. The m...

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Bibliographic Details
Published in:Journal of liquid chromatography & related technologies 2004-01, Vol.27 (5), p.897-909
Main Authors: Primus, Thomas M., Kohler, Dennis J., Furcolow, Carol A., Goodall, Margaret J., Johnston, John J., Savarie, Peter J.
Format: Article
Language:English
Subjects:
Acetaminophen (CAS# 114-26-1)
Analysis
Biological and medical sciences
Boiga irregularis
Brown treesnake
General pharmacology
High-performance liquid chromatography
Medical sciences
Pharmacology. Drug treatments
Tissue
UV detection
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Summary:Acetaminophen was extracted from brown treesnakes (Boiga irregularis) and analyzed by reversed-phase high-performance liquid chromatography (HPLC). Acetaminophen was quantified by UV absorbance at 250 nm. Recoveries were determined by analyzing acetaminophen-fortified blank homogenized tissue. The mean recovery of acetaminophen in whole body brown treesnakes was 87.9% ± 5.9% and 92.2% ± 5.8% for the fortification levels of 20 and 2400 µg/g, respectively. The method's limit of detection (MLOD) with UV detection was 0.70 µg/g.
ISSN:1082-6076
1520-572X
DOI:10.1081/JLC-120029706