Hyperbranched polyester polyacids and their binary systems with surfactants for doxorubicin encapsulation

Doxorubicin fixation by hyperbranched polyester polyol Boltorn H acid derivatives and their binary systems in the presence of a surfactant (Brij-35, Triton X-100) was investigated. Doxorubicin fixation degree nonlinearly depends on the number of acid groups in the polyester polyacid. Polyacid/surfac...

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Bibliographic Details
Published in:Fluid phase equilibria 2016-03, Vol.411, p.93-100
Main Authors: Khannanov, Artur A., Kutyreva, Marianna P., Ulakhovich, Nikolay A., Gataulina, Alfiya R., Bondar, Olga V., Zakharova, Lucia Ya, Kutyrev, Gennadiy A.
Format: Article
Language:English
Subjects:
Binary systems
Boltorn H hyperbranched polyester polyols
Derivatives
Doxorubicin
Drug encapsulation
Fixation
Hyperbranched polyester polyacids
Polyacids
Polyester resins
Polymer/surfactant binary systems
Polyols
Surfactants
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Summary:Doxorubicin fixation by hyperbranched polyester polyol Boltorn H acid derivatives and their binary systems in the presence of a surfactant (Brij-35, Triton X-100) was investigated. Doxorubicin fixation degree nonlinearly depends on the number of acid groups in the polyester polyacid. Polyacid/surfactant binary systems fix up to 60% of doxorubicin from the solution. [Display omitted] •Binary systems based on modified Boltorn H and a surfactant for doxorubicin encapsulation.•The effect of Boltorn H functionalization degree on doxorubicin encapsulation degree.•The effect of polymer/surfactant concentration ratio on doxorubicin encapsulation degree.
ISSN:0378-3812
1879-0224
DOI:10.1016/j.fluid.2015.12.023