Photoresponsive self-healing supramolecular hydrogels for light-induced release of DNA and doxorubicin

An azobenzene-containing cyclic dipeptide PAP-DKP-Lys is a photoresponsive low-MW hydrogelator. The gelation process can be triggered with temperature, pH, light, and ionic strength. The resulting self-healing gels can encapsulate dsDNA or an anticancer drug doxorubicin, and release them in a light-...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (15), p.3143-3146
Main Authors: Pianowski, Zbigniew L, Karcher, Johannes, Schneider, Knut
Format: Article
Language:English
Subjects:
Deoxyribonucleic acid
DNA - chemistry
Doxorubicin
Doxorubicin - chemistry
Drugs
Encapsulation
Gelation
Gels
Hydrogels
Hydrogels - chemistry
Light
Microscopy, Electron, Scanning
Osmolar Concentration
Photochemical Processes
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Summary:An azobenzene-containing cyclic dipeptide PAP-DKP-Lys is a photoresponsive low-MW hydrogelator. The gelation process can be triggered with temperature, pH, light, and ionic strength. The resulting self-healing gels can encapsulate dsDNA or an anticancer drug doxorubicin, and release them in a light-dependent manner. Biopolymers and bioactive small molecules are released with light from hydrogels formed by an azobenzene-containing cyclic dipeptide PAP-DKP-Lys.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc09633b