Perfluoroalkylchain conjugation as a new tactic for enhancing cell permeability of peptide nucleic acids (PNAs) viareducing the nanoparticle size

Perfluoro undecanoyl chain conjugated peptide nucleic acids (PNAs) show 2.5 to 3 fold higher cellular uptake efficiency in NIH 3T3 and HeLa cells compared to simple undecanoyl PNAs. Fluorination of PNAs leads to the formation of lower size ( similar to 100-250 nm) nanoparticles compared to larger si...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-12, Vol.52 (3), p.521-524
Main Authors: Ellipilli, Satheesh, vasudeva Murthy, Raghavendra, Ganesh, Krishna N
Format: Article
Language:English
Subjects:
Chains
Conjugation
Nanoparticles
Nanostructure
Nucleic acids
Penetration
Peptides
Uptakes
Online Access:Get full text
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Summary:Perfluoro undecanoyl chain conjugated peptide nucleic acids (PNAs) show 2.5 to 3 fold higher cellular uptake efficiency in NIH 3T3 and HeLa cells compared to simple undecanoyl PNAs. Fluorination of PNAs leads to the formation of lower size ( similar to 100-250 nm) nanoparticles compared to larger size ( similar to 500 nm) nanoparticles from non-fluorinated PNAs, thereby improving the efficiency of cell penetration.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc05342k