Rapid Reversible Photoswitching of Integrin-Mediated Adhesion at the Single-Cell Level

Rapid and reversible photoswitching of cell adhesion is achieved by c(RGDfK)‐azobenzenes embedded in a poly(ethylene glycol) background on surfaces. The light‐induced cis–trans‐isomerization of the azobenzene enables switching of cell adhesion on the surface. Reversibility of switching over several...

Full description

Saved in:
Bibliographic Details
Published in:Advanced materials (Weinheim) 2016-03, Vol.28 (9), p.1799-1802
Main Authors: Kadem, Laith F., Holz, Michelle, Suana, Kristine Grace, Li, Qian, Lamprecht, Constanze, Herges, Rainer, Selhuber-Unkel, Christine
Format: Article
Language:English
Subjects:
Adhesion
atomic force microscopy
Azo Compounds - chemistry
Azo Compounds - metabolism
Azo Compounds - pharmacology
Cell adhesion
Cell Adhesion - drug effects
Cell Line
Fibroblasts - cytology
Fibroblasts - drug effects
Fibroblasts - metabolism
Glycols
integrin
Integrins - metabolism
Light
Peptides, Cyclic - chemistry
photoswitching
Single-Cell Analysis
Spectroscopy
surface chemistry
Surface Properties
Switching
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Rapid and reversible photoswitching of cell adhesion is achieved by c(RGDfK)‐azobenzenes embedded in a poly(ethylene glycol) background on surfaces. The light‐induced cis–trans‐isomerization of the azobenzene enables switching of cell adhesion on the surface. Reversibility of switching over several consecutive switching cycles is demonstrated by single‐cell force spectroscopy.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201504394