Bottom-Up Engineering of Well-Defined 3D Microtissues Using Microplatforms and Biomedical Applications

During the last decades, the engineering of well‐defined 3D tissues has attracted great attention because it provides in vivo mimicking environment and can be a building block for the engineering of bioartificial organs. In this Review, diverse engineering methods of 3D tissues using microscale devi...

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Bibliographic Details
Published in:Advanced healthcare materials 2016-01, Vol.5 (1), p.56-74
Main Authors: Lee, Geon Hui, Lee, Jae Seo, Wang, Xiaohong, Hoon Lee, Sang
Format: Article
Language:English
Subjects:
3D cultures
Assembly
Biomedical materials
Biomedical Technology - methods
Encapsulation
Engineering
Health care
Humans
Microfluidics
Microtechnology - methods
microtissue
Organs
Platforms
regenerative medicine
self-assembly
Spheroids, Cellular - cytology
Three dimensional
tissue engineering
Tissue Engineering - methods
Tissue Scaffolds - chemistry
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Summary:During the last decades, the engineering of well‐defined 3D tissues has attracted great attention because it provides in vivo mimicking environment and can be a building block for the engineering of bioartificial organs. In this Review, diverse engineering methods of 3D tissues using microscale devices are introduced. Recent progress of microtechnologies has enabled the development of microplatforms for bottom‐up assembly of diverse shaped 3D tissues consisting of various cells. Micro hanging‐drop plates, microfluidic chips, and arrayed microwells are the typical examples. The encapsulation of cells in hydrogel microspheres and microfibers allows the engineering of 3D microtissues with diverse shapes. Applications of 3D microtissues in biomedical fields are described, and the future direction of microplatform‐based engineering of 3D micro‐tissues is discussed. Engineering of 3D tissues, which are building blocks for the bottom‐up engineering, has been widely developed with the advances of micro‐technologies. This article gives an overview of those micro‐technologies that facilitate providing well defined 3D tissues and in vivo mimicking platforms, and reports the applications of 3D tissues and future directions.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201500107