Square Wave Cathodic Adsorptive Stripping Voltammetric Determination of the Anticancer Drugs Flutamide and Irinotecan in Biological Fluids Using Renewable Pencil Graphite Electrodes

A sensitive electrochemical method based on square wave cathodic adsorptive stripping voltammetry (SWCASV) using pencil graphite electrodes (PGE) was developed for the individual and simultaneous determination of the anticancer drugs flutamide (Flu) and irinotecan (Irino) in biological fluids. Calib...

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Bibliographic Details
Published in:Electroanalysis (New York, N.Y.) N.Y.), 2016-02, Vol.28 (2), p.372-379
Main Authors: Temerk, Yassien M., Ibrahim, Hossieny S. M., Schuhmann, Wolfgang
Format: Article
Language:English
Subjects:
Biological
drug analysis
Drugs
Electrodes
Fluid dynamics
Fluid flow
Fluids
flutamide
irinotecan
pencil graphite electrode
Square waves
Stripping
voltammetry
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Summary:A sensitive electrochemical method based on square wave cathodic adsorptive stripping voltammetry (SWCASV) using pencil graphite electrodes (PGE) was developed for the individual and simultaneous determination of the anticancer drugs flutamide (Flu) and irinotecan (Irino) in biological fluids. Calibration curves showed an excellent linear response with limits of detection of 1.68×10−9 and 1.55×10−8 M Irino and Flu, respectively. The statistical evaluation of within‐day repeatability (n=5) and day to day precision (n=5) showed satisfactory accuracy and precision. SWCASV using a PGE for individual and simultaneous determination of both drugs in bulk form, human urine and serum samples was demonstrated.
ISSN:1040-0397
1521-4109
DOI:10.1002/elan.201500329