A Lysosome-Targeting AIEgen for Autophagy Visualization

In this work, a morpholine‐functionalized aggregation‐induced emission luminogen (AIEgen), AIE‐LysoY, is reported for lysosomal imaging and autophagy visualization. To attain outstanding imaging contrast, AIE‐LysoY is equipped with excited state intramolecular proton transfer (ESIPT) characteristic....

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Bibliographic Details
Published in:Advanced healthcare materials 2016-02, Vol.5 (4), p.427-431
Main Authors: Leung, Chris Wai Tung, Wang, Zhiming, Zhao, Engui, Hong, Yuning, Chen, Sijie, Kwok, Ryan Tsz Kin, Leung, Anakin Chun Sing, Wen, Rongsen, Li, Bingshi, Lam, Jacky Wing Yip, Tang, Ben Zhong
Format: Article
Language:English
Subjects:
aggregation-induced emission
Autophagy
Biocompatible Materials - chemistry
Cell Survival
Emission
Fluid flow
Health care
HeLa Cells
Humans
Imaging
lysosome imaging
Lysosomes
Lysosomes - metabolism
Microscopy, Fluorescence
Molecular Probes - chemistry
Morpholines - chemistry
Platforms
Protons
rapamycin
Signal to noise ratio
Visualization
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Summary:In this work, a morpholine‐functionalized aggregation‐induced emission luminogen (AIEgen), AIE‐LysoY, is reported for lysosomal imaging and autophagy visualization. To attain outstanding imaging contrast, AIE‐LysoY is equipped with excited state intramolecular proton transfer (ESIPT) characteristic. AIE‐LysoY provides a new platform for lysosome visualization with good biocompatibility, large Stokes shift, superior signal‐to‐noise ratio, and high photostability.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201500674