A Lysosome-Targeting AIEgen for Autophagy Visualization

In this work, a morpholine‐functionalized aggregation‐induced emission luminogen (AIEgen), AIE‐LysoY, is reported for lysosomal imaging and autophagy visualization. To attain outstanding imaging contrast, AIE‐LysoY is equipped with excited state intramolecular proton transfer (ESIPT) characteristic....

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Published in:Advanced healthcare materials 2016-02, Vol.5 (4), p.427-431
Main Authors: Leung, Chris Wai Tung, Wang, Zhiming, Zhao, Engui, Hong, Yuning, Chen, Sijie, Kwok, Ryan Tsz Kin, Leung, Anakin Chun Sing, Wen, Rongsen, Li, Bingshi, Lam, Jacky Wing Yip, Tang, Ben Zhong
Format: Article
Language:English
Subjects:
aggregation-induced emission
Autophagy
Biocompatible Materials - chemistry
Cell Survival
Emission
Fluid flow
Health care
HeLa Cells
Humans
Imaging
lysosome imaging
Lysosomes
Lysosomes - metabolism
Microscopy, Fluorescence
Molecular Probes - chemistry
Morpholines - chemistry
Platforms
Protons
rapamycin
Signal to noise ratio
Visualization
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cited_by cdi_FETCH-LOGICAL-c5174-450d27f4c942c833e3720f0daaaae4b712d916850cb076fcc8e01d2fb68ad1073
cites cdi_FETCH-LOGICAL-c5174-450d27f4c942c833e3720f0daaaae4b712d916850cb076fcc8e01d2fb68ad1073
container_end_page 431
container_issue 4
container_start_page 427
container_title Advanced healthcare materials
container_volume 5
creator Leung, Chris Wai Tung
Wang, Zhiming
Zhao, Engui
Hong, Yuning
Chen, Sijie
Kwok, Ryan Tsz Kin
Leung, Anakin Chun Sing
Wen, Rongsen
Li, Bingshi
Lam, Jacky Wing Yip
Tang, Ben Zhong
description In this work, a morpholine‐functionalized aggregation‐induced emission luminogen (AIEgen), AIE‐LysoY, is reported for lysosomal imaging and autophagy visualization. To attain outstanding imaging contrast, AIE‐LysoY is equipped with excited state intramolecular proton transfer (ESIPT) characteristic. AIE‐LysoY provides a new platform for lysosome visualization with good biocompatibility, large Stokes shift, superior signal‐to‐noise ratio, and high photostability.
doi_str_mv 10.1002/adhm.201500674
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subjects aggregation-induced emission
Autophagy
Biocompatible Materials - chemistry
Cell Survival
Emission
Fluid flow
Health care
HeLa Cells
Humans
Imaging
lysosome imaging
Lysosomes
Lysosomes - metabolism
Microscopy, Fluorescence
Molecular Probes - chemistry
Morpholines - chemistry
Platforms
Protons
rapamycin
Signal to noise ratio
Visualization
title A Lysosome-Targeting AIEgen for Autophagy Visualization
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