One-Step Photo Synthesis of Protein-Drug Nanoassemblies for Drug Delivery

Upon controlled UV illumination, disulfide bonds in bovine α‐lactalbumin (BLA) are selectively broken, leading to self‐assembly of the BLA and doxorubicin (DOX) molecules into nanoparticles via hydrophobic interactions and intermolecular disulfide bonds. Such protein–drug nanoparticles have synergis...

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Bibliographic Details
Published in:Advanced healthcare materials 2013-06, Vol.2 (6), p.795-799
Main Authors: Xie, Jinbing, Cao, Yi, Xia, Mao, Gao, Xiang, Qin, Meng, Wei, Jiwu, Wang, Wei
Format: Article
Language:English
Subjects:
Animals
Anticancer properties
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - chemistry
Antitumor activity
bovine a-lactalbumin
Cell Line, Tumor
Disulfide bonds
Disulfides
Doxorubicin
Doxorubicin - administration & dosage
Doxorubicin - chemistry
Drug delivery
Drug delivery systems
Health care
Hydrophobicity
Illumination
Lactalbumin
Lactalbumin - administration & dosage
Lactalbumin - chemistry
Light
Mice
Nanocapsules - administration & dosage
Nanocapsules - chemistry
Nanocapsules - radiation effects
Nanoparticles
Neoplasms, Experimental - drug therapy
Neoplasms, Experimental - pathology
Oleic Acid - administration & dosage
Oleic Acid - chemistry
Photochemistry - methods
Protein biosynthesis
Protein synthesis
Proteins
Self assembly
Treatment Outcome
Tumors
UV illumination
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Summary:Upon controlled UV illumination, disulfide bonds in bovine α‐lactalbumin (BLA) are selectively broken, leading to self‐assembly of the BLA and doxorubicin (DOX) molecules into nanoparticles via hydrophobic interactions and intermolecular disulfide bonds. Such protein–drug nanoparticles have synergistic anticancer activity in vitro and tumor‐homing specificity in vivo, which are of great potential for systemic drug delivery in cancer therapy.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201200285