Biodegradable Peptide-Silica Nanodonuts

We report hybrid organosilica toroidal particles containing a short peptide sequence as the organic component of the hybrid systems. Once internalised in cancer cells, the presence of the peptide allows for interaction with peptidase enzymes, which attack the nanocarrier effectively triggering its s...

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Bibliographic Details
Published in:Chemistry : a European journal 2016-03, Vol.22 (11), p.3697-3703
Main Authors: Maggini, Laura, Travaglini, Leana, Cabrera, Ingrid, Castro-Hartmann, Pablo, De Cola, Luisa
Format: Article
Language:English
Subjects:
Aminopeptidases - chemistry
Aminopeptidases - metabolism
Biodegradability
breakable particles
Breakdown
Carriers
Carriers, Drug
Chemistry
Doxorubicin - chemistry
drug delivery
Drug Delivery Systems
HeLa Cells
Humans
hybrid organosilica particles
materials science
Nanoparticles - chemistry
Nanostructure
Peptidases
Peptides
Peptides - chemistry
Silicon Dioxide - chemistry
Uptakes
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Summary:We report hybrid organosilica toroidal particles containing a short peptide sequence as the organic component of the hybrid systems. Once internalised in cancer cells, the presence of the peptide allows for interaction with peptidase enzymes, which attack the nanocarrier effectively triggering its structural breakdown. Moreover, these biodegradable nanovectors are characterised by high cellular uptake and exocytosis, showing great potential as biodegradable drug carriers. To demonstrate this feature, doxorubicin was employed and its delivery in HeLa cells investigated. Breakable nanodonuts: Hybrid organosilica toroidal particles (see figure) containing a short peptide sequence as the organic component are reported. Once internalised in cancer cells, peptidase enzymes attack the nanocarriers effectively triggering their structural breakdown. These biodegradable nanovectors are also characterised by high cellular uptake and exocytosis, and therefore they have been challenged as biodegradable drug carriers.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201504605