A Hydrophobic Dye-Encapsulated Nano-Hybrid as an Efficient Fluorescent Probe for Living Cell Imaging

Water‐soluble hydrophobic‐dye@nano‐hybrids (DPN@NHs) with extraordinarily enhanced fluorescent performance were fabricated by encapsulating the hydrophobic dye molecules into the core of the hybrid nanospheres based on the self‐assembly of amphiphilic block copolymers followed by shell cross‐linking...

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Bibliographic Details
Published in:Advanced healthcare materials 2012-07, Vol.1 (4), p.475-479
Main Authors: Chang, Shu, Wu, Xumeng, Li, Yongsheng, Niu, Dechao, Ma, Zhi, Zhao, Wenru, Gu, Jinlou, Dong, Wenjie, Ding, Feng, Zhu, Weihong, Shi, Jianlin
Format: Article
Language:English
Subjects:
Block copolymers
Cells (biology)
Contrast Media - chemistry
Dyes
Fluorescence
Fluorescent Dyes - chemistry
Health care
high quantum yield
Hydrophobic and Hydrophilic Interactions
hydrophobic fluorescent dye
Image Enhancement - methods
living-cell imaging
Microscopy, Fluorescence - methods
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Nanospheres
Nanostructure
Self assembly
water-solubility
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Summary:Water‐soluble hydrophobic‐dye@nano‐hybrids (DPN@NHs) with extraordinarily enhanced fluorescent performance were fabricated by encapsulating the hydrophobic dye molecules into the core of the hybrid nanospheres based on the self‐assembly of amphiphilic block copolymers followed by shell cross‐linking using 3‐mercaptopropyltrimethoxy‐silane. The DPN@NHs are 50 nm in size, are monodispersed in aqueous solution and have a quantum yield enhanced by 30 times.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201200144