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Chitosan Electrodeposition for Microrobotic Drug Delivery
A method to functionalize steerable magnetic microdevices through the co‐electrodeposition of drug loaded chitosan hydrogels is presented. The characteristics of the polymer matrix have been investigated in terms of fabrication, morphology, drug release and response to different environmental condit...
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Published in: | Advanced healthcare materials 2013-07, Vol.2 (7), p.1037-1044 |
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container_title | Advanced healthcare materials |
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creator | Fusco, Stefano Chatzipirpiridis, George Sivaraman, Kartik M. Ergeneman, Olgaç Nelson, Bradley J. Pané, Salvador |
description | A method to functionalize steerable magnetic microdevices through the co‐electrodeposition of drug loaded chitosan hydrogels is presented. The characteristics of the polymer matrix have been investigated in terms of fabrication, morphology, drug release and response to different environmental conditions. Modifications of the matrix behavior could be achieved by simple chemical post processing. The system is able to load and deliver 40–80 μg cm−2 of a model drug (Brilliant Green) in a sustained manner with different profiles. Chitosan allows a pH responsive behavior with faster and more efficient release under slightly acidic conditions as can be present in tumor or inflamed tissue. A prototype of a microrobot functionalized with the hydrogel is presented and proposed for the treatment of posterior eye diseases.
Chitosan drug loaded matrices are electrodeposited on conductive surfaces and modified by simple dip coating processes with an ionic crosslinker solution. Drug release is evaluated in different pH conditions mimicking possible changes due to local inflammation or disease. The method is intended to functionalize capsules for drug delivery into the eye. |
doi_str_mv | 10.1002/adhm.201200409 |
format | article |
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Chitosan drug loaded matrices are electrodeposited on conductive surfaces and modified by simple dip coating processes with an ionic crosslinker solution. Drug release is evaluated in different pH conditions mimicking possible changes due to local inflammation or disease. The method is intended to functionalize capsules for drug delivery into the eye.</description><identifier>ISSN: 2192-2640</identifier><identifier>EISSN: 2192-2659</identifier><identifier>DOI: 10.1002/adhm.201200409</identifier><identifier>PMID: 23355508</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Chitosan ; Chitosan - chemistry ; drug delivery ; Drug Delivery Systems ; Drugs ; Electrochemical Techniques ; electrodeposition ; Eyes ; Hydrogels ; Immersion coating ; microrobotics ; Microrobots ; Microscopy, Electron, Scanning ; Robotics ; smart materials</subject><ispartof>Advanced healthcare materials, 2013-07, Vol.2 (7), p.1037-1044</ispartof><rights>Copyright © 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4779-5c821b690c1573294bb78341b50d50057b5469ca1521ac9c81246ab61a14f9813</citedby><cites>FETCH-LOGICAL-c4779-5c821b690c1573294bb78341b50d50057b5469ca1521ac9c81246ab61a14f9813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23355508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fusco, Stefano</creatorcontrib><creatorcontrib>Chatzipirpiridis, George</creatorcontrib><creatorcontrib>Sivaraman, Kartik M.</creatorcontrib><creatorcontrib>Ergeneman, Olgaç</creatorcontrib><creatorcontrib>Nelson, Bradley J.</creatorcontrib><creatorcontrib>Pané, Salvador</creatorcontrib><title>Chitosan Electrodeposition for Microrobotic Drug Delivery</title><title>Advanced healthcare materials</title><addtitle>Advanced Healthcare Materials</addtitle><description>A method to functionalize steerable magnetic microdevices through the co‐electrodeposition of drug loaded chitosan hydrogels is presented. The characteristics of the polymer matrix have been investigated in terms of fabrication, morphology, drug release and response to different environmental conditions. Modifications of the matrix behavior could be achieved by simple chemical post processing. The system is able to load and deliver 40–80 μg cm−2 of a model drug (Brilliant Green) in a sustained manner with different profiles. Chitosan allows a pH responsive behavior with faster and more efficient release under slightly acidic conditions as can be present in tumor or inflamed tissue. A prototype of a microrobot functionalized with the hydrogel is presented and proposed for the treatment of posterior eye diseases.
Chitosan drug loaded matrices are electrodeposited on conductive surfaces and modified by simple dip coating processes with an ionic crosslinker solution. Drug release is evaluated in different pH conditions mimicking possible changes due to local inflammation or disease. The method is intended to functionalize capsules for drug delivery into the eye.</description><subject>Chitosan</subject><subject>Chitosan - chemistry</subject><subject>drug delivery</subject><subject>Drug Delivery Systems</subject><subject>Drugs</subject><subject>Electrochemical Techniques</subject><subject>electrodeposition</subject><subject>Eyes</subject><subject>Hydrogels</subject><subject>Immersion coating</subject><subject>microrobotics</subject><subject>Microrobots</subject><subject>Microscopy, Electron, Scanning</subject><subject>Robotics</subject><subject>smart materials</subject><issn>2192-2640</issn><issn>2192-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqNkU1LKzEUhoNcUVG3LmXAzd1MzcnnZCkdreIXguIyZNL0Gu-0qcmM2n9vpFrEjWaTLJ7zkPe8CO0BHgDG5NCMH6YDgoFgzLBaQ1sEFCmJ4OrP6s3wJtpN6RHnIziICjbQJqGUc46rLaSGD74LycyK49bZLoaxm4fkOx9mxSTE4tLbGGJoQudtUcf-X1G71j-7uNhB6xPTJrf7cW-ju5Pj2-FpeXE9OhseXZSWSalKbisCjVDYApeUKNY0sqIMGo7HHGMuG86EsgY4AWOVrYAwYRoBBthEVUC30d-ldx7DU-9Sp6c-Wde2ZuZCnzRUOX1W0l-gUgohFCPkZ5QqxbHMf8nowTf0MfRxljNnYd51jlmxTA2WVN5XStFN9Dz6qYkLDVi_t6Xf29KrtvLA_oe2b6ZuvMI_u8mAWgIvvnWLH3T6qD69_Covl7M-de51NWvify0klVzfX430zdV5TUe11DV9A5K0q5c</recordid><startdate>201307</startdate><enddate>201307</enddate><creator>Fusco, Stefano</creator><creator>Chatzipirpiridis, George</creator><creator>Sivaraman, Kartik M.</creator><creator>Ergeneman, Olgaç</creator><creator>Nelson, Bradley J.</creator><creator>Pané, Salvador</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T5</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7TO</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope><scope>7QO</scope><scope>P64</scope></search><sort><creationdate>201307</creationdate><title>Chitosan Electrodeposition for Microrobotic Drug Delivery</title><author>Fusco, Stefano ; 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Chitosan drug loaded matrices are electrodeposited on conductive surfaces and modified by simple dip coating processes with an ionic crosslinker solution. Drug release is evaluated in different pH conditions mimicking possible changes due to local inflammation or disease. The method is intended to functionalize capsules for drug delivery into the eye.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>23355508</pmid><doi>10.1002/adhm.201200409</doi><tpages>8</tpages></addata></record> |
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subjects | Chitosan Chitosan - chemistry drug delivery Drug Delivery Systems Drugs Electrochemical Techniques electrodeposition Eyes Hydrogels Immersion coating microrobotics Microrobots Microscopy, Electron, Scanning Robotics smart materials |
title | Chitosan Electrodeposition for Microrobotic Drug Delivery |
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