Fluorescent microspheres of poly(ethylene glycol)-poly(lactic acid)-fluorescein copolymers synthesized by Ugi four-component condensation

ABSTRACT Microparticles formed by poly(lactic acid) (PLA) and poly(ethylene glycol) (PEG) diblock copolymers containing fluorescein grafted to the polymer chain were synthesized by a Ugi four‐component condensation (UFCC) reaction. To synthesize these copolymers, lactide was first polymerized by a r...

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Bibliographic Details
Published in:Journal of applied polymer science 2016-03, Vol.133 (9), p.np-n/a
Main Authors: Icart, Luis P., Fernandes, Edson, Agüero, Lissette, Ramón, Jose, Zaldivar, Dionisio, Dias, Marcos L.
Format: Article
Language:English
Subjects:
Alcohols
biodegradable
biomedical applications
Chain reactions
Copolymers
drug-delivery systems
Fluorescein
Fluorescence
Materials science
Microspheres
Polymerization
Polymers
Thermal properties
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Summary:ABSTRACT Microparticles formed by poly(lactic acid) (PLA) and poly(ethylene glycol) (PEG) diblock copolymers containing fluorescein grafted to the polymer chain were synthesized by a Ugi four‐component condensation (UFCC) reaction. To synthesize these copolymers, lactide was first polymerized by a ring‐opening polymerization with alcohol initiators containing functional groups to give carboxyl‐ and aldehyde‐end‐functionalized PLA. Two different fluorescent block copolymers (FCPs) of PEG–PLA conjugated to fluorescein (FCP 1 and FCP 2) were then synthesized by UFCC; they gave yields in the range 65–75%. These copolymers were characterized well according their chemical structures and thermal properties, and we prepared fluorescent microspheres (FMSs) from them with the single emulsion–solvent evaporation method (FMS 1 and FMS 2). A new application of UFCC in the preparation of biomasked drug‐delivery systems is proposed. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 42994.
ISSN:0021-8995
1097-4628
DOI:10.1002/app.42994