The rare transformation of 2,7-diazaspiro[4.4]nonanes in furo[3,4-c]pyridines

Transformation of 3-amino-8-hydroxy-1,6-dioxo-2,7-diazaspiro[4.4]non-3-en-4-carbonitriles in concentrated hydrohalic acid media leads to the obtaining of two classes of fused heterocycles: 4-halogen-3-hydroxy-1,3-dihydrofuro[3,4- c ]pyridin-1-ones and octahydropyrrolo[3,4- c ]pyrrole-1,3,4,6-tetraon...

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Bibliographic Details
Published in:RSC advances 2016-01, Vol.6 (13), p.1597-16
Main Authors: Fedoseev, Sergey V, Ershov, Oleg V, Lipin, Konstantin V, Belikov, Mikhail Yu
Format: Article
Language:English
Subjects:
Media
Transformations
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Summary:Transformation of 3-amino-8-hydroxy-1,6-dioxo-2,7-diazaspiro[4.4]non-3-en-4-carbonitriles in concentrated hydrohalic acid media leads to the obtaining of two classes of fused heterocycles: 4-halogen-3-hydroxy-1,3-dihydrofuro[3,4- c ]pyridin-1-ones and octahydropyrrolo[3,4- c ]pyrrole-1,3,4,6-tetraones. Transformation of 3-amino-8-hydroxy-1,6-dioxo-2,7-diazaspiro[4.4]non-3-en-4-carbonitriles to the obtaining of two classes fused heterocycles: 4-halogen-3-hydroxy-1,3-dihydrofuro[3,4- c ]pyridin-1-ones and octahydropyrrolo[3,4- c ]pyrrole-1,3,4,6-tetraones.
ISSN:2046-2069
2046-2069
DOI:10.1039/c5ra27585g