Flash Generation of a Highly Reactive Pd Catalyst for Suzuki-Miyaura Coupling by Using a Flow Microreactor

Superflash! Flash chemistry enables the use of highly reactive unstable species as catalysts for chemical synthesis. Fast micromixing of a solution of [Pd(OAc)2] and that of tBu3P in 1:1 mole ratio gave a solution of a highly reactive unstable species, which was immediately transferred to a vessel b...

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Bibliographic Details
Published in:Chemistry : a European journal 2012-09, Vol.18 (38), p.11871-11875
Main Authors: Nagaki, Aiichiro, Takabayashi, Naofumi, Moriwaki, Yuya, Yoshida, Jun-ichi
Format: Article
Language:English
Subjects:
Catalysts
Chemistry
Coupling
cross-coupling
Micromixing
Microreactors
Moles
Palladium
Suzuki-Miyaura coupling
Synthesis (chemistry)
Vessels
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Summary:Superflash! Flash chemistry enables the use of highly reactive unstable species as catalysts for chemical synthesis. Fast micromixing of a solution of [Pd(OAc)2] and that of tBu3P in 1:1 mole ratio gave a solution of a highly reactive unstable species, which was immediately transferred to a vessel by using a flow microreactor, in which Suzuki–Miyaura coupling was conducted (see scheme).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201201579