Well-Defined Macromolecules Using Horseradish Peroxidase as a RAFT Initiase

Enzymatic catalysis and control over macromolecular architectures from reversible addition‐fragmentation chain transfer polymerization (RAFT) are combined to give a new method of making polymers. Horseradish peroxidase (HRP) is used to catalytically generate radicals using hydrogen peroxide and acet...

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Bibliographic Details
Published in:Macromolecular rapid communications. 2016-02, Vol.37 (4), p.362-367
Main Authors: Danielson, Alex P., Van Kuren, Dylan Bailey, Lucius, Melissa E., Makaroff, Katherine, Williams, Cameron, Page, Richard C., Berberich, Jason A., Konkolewicz, Dominik
Format: Article
Language:English
Subjects:
Addition polymerization
Architecture
Biocatalysis
Catalysis
Conjugates
enzyme catalysis
Free Radicals - chemistry
heme proteins
Horseradish Peroxidase - chemistry
Kinetics
Molecular Structure
Peroxidase
Polymerization
Polymers - chemical synthesis
Polymers - chemistry
protein modifications
Radicals
raft polymerization
Rafts
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Summary:Enzymatic catalysis and control over macromolecular architectures from reversible addition‐fragmentation chain transfer polymerization (RAFT) are combined to give a new method of making polymers. Horseradish peroxidase (HRP) is used to catalytically generate radicals using hydrogen peroxide and acetylacetone as a mediator. RAFT is used to control the polymer structure. HRP catalyzed RAFT polymerization gives acrylate and acrylamide polymers with relatively narrow molecular weight distributions. The polymerization is rapid, typically exceeding 90% monomer conversion in 30 min. Complex macromolecular architectures including a block copolymer and a protein‐polymer conjugate are synthesized using HRP to catalytically initiate RAFT polymerization. RAFT polymerization is performed using horseradish peroxidase to catalytically generate radicals. Well‐defined homo, block polymers are synthesized as well as a protein‐polymer conjugate
ISSN:1022-1336
1521-3927
DOI:10.1002/marc.201500633