Magnesium-containing mixed coatings on zirconia for dental implants: mechanical characterization and in vitro behavior

An important challenge in the field of dental and orthopedic implantology is the preparation of implant coatings with bioactive functions that feature a high mechanical stability and at the same time mimic structural and compositional properties of native bone for a better bone ingrowth. This study...

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Bibliographic Details
Published in:Journal of biomaterials applications 2015-07, Vol.30 (1), p.104-118
Main Authors: Pardun, Karoline, Treccani, Laura, Volkmann, Eike, Streckbein, Philipp, Heiss, Christian, Gerlach, Juergen W, Maendl, Stephan, Rezwan, Kurosch
Format: Article
Language:English
Subjects:
Animals
Bones
Calcium Phosphates - chemistry
Cattle
Cell Differentiation - drug effects
Cell Line
Cell Proliferation - drug effects
Coated Materials, Biocompatible - chemistry
Coatings
Dental Implants
Humans
In vitro testing
Magnesium
Magnesium - chemistry
Materials Testing
Osteoblasts - cytology
Phosphate coatings
Solubility
Surface Properties
Surgical implants
Yttria stabilized zirconia
Zirconium - chemistry
Zirconium dioxide
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Summary:An important challenge in the field of dental and orthopedic implantology is the preparation of implant coatings with bioactive functions that feature a high mechanical stability and at the same time mimic structural and compositional properties of native bone for a better bone ingrowth. This study investigates the influence of magnesium addition to zirconia-calcium phosphate coatings. The mixed coatings were prepared with varying additions of either magnesium oxide or magnesium fluoride to yttria-stabilized zirconia and hydroxyapatite. The coatings were deposited on zirconia discs and screw implants by wet powder spraying. Microstructure studies confirm a porous coating with similar roughness and firm adhesion not hampered by the coating composition. The coating morphology, mechanical flexural strength and calcium dissolution showed a magnesium content-dependent effect. Moreover, the in vitro results obtained with human osteoblasts reveal an improved biological performance caused by the presence of Mg2+ ions. The magnesium-containing coatings exhibited better cell proliferation and differentiation in comparison to pure zirconia-calcium phosphate coatings. In conclusion, these results demonstrate that magnesium addition increases the bioactivity potential of zirconia-calcium phosphate coatings and is thus a highly suitable candidate for bone implant coatings.
ISSN:0885-3282
1530-8022
DOI:10.1177/0885328215572428