Determination of residual levels of naloxone, yohimbine, thiophanate, and altrenogest in porcine muscle using QuEChERS with liquid chromatography and triple quadrupole mass spectrometry

A quick, easy, cheap, effective, rugged, and safe QuEChERS (method) was used for the simultaneous detection of four veterinary drug residues, namely naloxone, yohimbine, thiophanate, and altrenogest, in porcine muscle, using liquid chromatography with electrospray ionization triple quadrupole tandem...

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Bibliographic Details
Published in:Journal of separation science 2016-03, Vol.39 (5), p.835-841
Main Authors: Zhang, Dan, Park, Jin‐A, Kim, Seong‐Kwan, Cho, Sang‐Hyun, Cho, Soo‐Min, Yi, Hee, Shim, Jae‐Han, Kim, Jin‐Suk, Abd El‐Aty, A. M, Shin, Ho‐Chul
Format: Article
Language:English
Subjects:
animal tissues
Animals
Calibration
Chromatography
Chromatography, High Pressure Liquid
drug residues
Drug Residues - analysis
Drug Residues - isolation & purification
Drugs
Food Contamination - analysis
ionization
Ions
Limit of Detection
Liquid chromatography
markets
Mass spectrometry
Meat - analysis
Muscles
Muscles - chemistry
naloxone
Naloxone - analysis
Naloxone - isolation & purification
Porcine muscle
Quadrupoles
Residue analysis
Sample preparation
Scientific imaging
Solid Phase Extraction - methods
Standard deviation
Swine
Tandem Mass Spectrometry
Thiophanate - analysis
Thiophanate - isolation & purification
Trenbolone Acetate - analogs & derivatives
Trenbolone Acetate - analysis
Trenbolone Acetate - isolation & purification
Triple quadrupole tandem mass spectrometry
Veterinary
Veterinary drugs
Veterinary Drugs - analysis
Veterinary Drugs - isolation & purification
yohimbine
Yohimbine - analysis
Yohimbine - isolation & purification
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Summary:A quick, easy, cheap, effective, rugged, and safe QuEChERS (method) was used for the simultaneous detection of four veterinary drug residues, namely naloxone, yohimbine, thiophanate, and altrenogest, in porcine muscle, using liquid chromatography with electrospray ionization triple quadrupole tandem mass spectrometry. Because of the unavailability of a suitable internal standard, matrix‐matched calibrations were used for quantification, with determination coefficients ≥ 0.9542. The accuracy (expressed as recovery %) ranged from 60.53 to 83.25%, and the intra‐ and interday precisions (expressed as relative standard deviations) were
ISSN:1615-9306
1615-9314
DOI:10.1002/jssc.201501206