Sensing Conductive Hydrogels for Rapid Detection of Cytokines in Blood

Conducting polymer hydrogel is fabricated atop gold or ITO electrodes and is functionalized with monoclonal antibodies. Binding of interferon‐γ molecules causes redox properties of conductive hydrogel to change in a concentration‐dependent fashion without the need for washing or sample handling step...

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Bibliographic Details
Published in:Advanced healthcare materials 2016-03, Vol.5 (6), p.659-664
Main Authors: Shin, Dong-Sik, Matharu, Zimple, You, Jungmok, Siltanen, Christian, Vu, Tam, Raghunathan, Vijay Krishna, Stybayeva, Gulnaz, Hill, Ashley E., Revzin, Alexander
Format: Article
Language:English
Subjects:
Animals
Binding
Biosensing Techniques
biosensors
Blood
Bridged Bicyclo Compounds, Heterocyclic - chemistry
Cattle
conducting polymer hydrogels
Conducting polymers
cytokine detection
Cytokines
Cytokines - blood
electrochemical detection
Electrochemical Techniques
Electrodes
Gold - chemistry
Health care
Hydrogels
Hydrogels - chemistry
immunoassays
Interferon-gamma - blood
Leukocytes, Mononuclear - cytology
Leukocytes, Mononuclear - metabolism
Monoclonal antibodies
Polymers - chemistry
Tin Compounds - chemistry
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Summary:Conducting polymer hydrogel is fabricated atop gold or ITO electrodes and is functionalized with monoclonal antibodies. Binding of interferon‐γ molecules causes redox properties of conductive hydrogel to change in a concentration‐dependent fashion without the need for washing or sample handling steps. This conductive hydrogel remains functional in a fouling media such as whole blood.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201500571