Effect of TiO sub(2) nanotubes arrays on osseointegration of orthodontic miniscrew

• Published in: Biomedical microdevices 2015-08, Vol.17 (4), p.1-7
• Main Authors: Jang, Insan, Shim, Seong-Cheol, Choi, Dong-Soon, Cha, Bong-Kuen, Lee, Jae-Kwan, Choe, Byung-Hak, Choi, Won-Youl
• Format: Article
• Language: English
• Subjects: Anodizing; Arrays; Bones; Contact; Nanotubes; Orthodontics; Stability; Titanium dioxide
• ISSN: 1387-2176; 1572-8781
• DOI: 10.1007/s10544-015-9986-1

To increase the stability of orthodontic miniscrews, TiO sub(2) nanotube arrays were fabricated on the surface of Ti miniscrews and the effect of those arrays on the osseointegration of miniscrews was evaluated. Highly ordered TiO sub(2) nanotube arrays were grown on the surface of orthodontic miniscrews. Ethylene glycol based electrolyte was used in the anodic oxidation process. Two-step anodic oxidation was conducted to obtain clean and open windows in TiO sub(2) nanotube arrays. The diameter and length of the TiO sub(2) nanotube arrays were ~ 70 nm and ~ 5 mu m, respectively. The miniscrews with TiO sub(2) nanotube arrays were implanted in the legs of New Zealand white rabbits for 8 weeks. Histological osseointegration was assessed by bone-to-implant contact ratio, and three-dimensional bone volume ratio was measured by micro-computed tomography analysis. The miniscrews with TiO sub(2) nanotube arrays had a greater mean bone-to-implant contact ratio of 52.8 % than the control, 29.3 %. Mean bone volume ratio (BV/TV) was also higher in the miniscrews with TiO sub(2) nanotube arrays, at 81.2 % than those in the control via micro-CT analysis. Our findings support that TiO sub(2) nanotube arrays on the surface of miniscrews enhance osseointegration and improve the stability of the miniscrew.