PolyDOPA Mussel-Inspired Coating as a Means for Hydroxyapatite Entrapment on Polytetrafluoroethylene Surface for Application in Periodontal Diseases

Inert polytetrafluoroethylene (PTFE) membranes for periodontal regeneration suffer from weak osteoconductive properties. In this work, a strategy for hydroxyapatite (HAp) coating on PTFE films through an adhesive layer of self‐polymerized 3,4‐dihydroxy‐DL‐phenylalanine (polyDOPA) was developed to im...

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Bibliographic Details
Published in:Macromolecular bioscience 2016-02, Vol.16 (2), p.288-298
Main Authors: Nardo, Tiziana, Chiono, Valeria, Ciardelli, Gianluca, Tabrizian, Maryam
Format: Article
Language:English
Subjects:
3,4‐dihydroxy‐DL‐phenylalanine (DOPA)
4-dihydroxy-DL-phenylalanine (DOPA)
Adhesion
Adhesives
Animals
Cell Line
Coated Materials, Biocompatible - chemistry
Coated Materials, Biocompatible - pharmacology
Coating
Durapatite - chemistry
Durapatite - pharmacology
Hydroxyapatite
Indoles - chemistry
Indoles - pharmacology
Materials Testing
Medical services
Membranes, Artificial
Mice
Periodontal disease
Periodontal Diseases - metabolism
Periodontal Diseases - therapy
Polymers - chemistry
Polymers - pharmacology
Polytetrafluoroethylene - chemistry
Polytetrafluoroethylene - pharmacology
polytetrafluoroethylene coating
Polytetrafluoroethylenes
scaffold
surface modification
Wettability
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Summary:Inert polytetrafluoroethylene (PTFE) membranes for periodontal regeneration suffer from weak osteoconductive properties. In this work, a strategy for hydroxyapatite (HAp) coating on PTFE films through an adhesive layer of self‐polymerized 3,4‐dihydroxy‐DL‐phenylalanine (polyDOPA) was developed to improve surface properties. Physico‐chemical and morphological analysis demonstrated the deposition of polyDOPA and HAp, with an increase in surface roughness and wettability. A discontinuous coating was present after 14 days in PBS and MC3T3‐E1 cells proliferation and adhesion were improved. Results confirmed the potential application of polyDOPA/HAp‐coated films for periodontal disease treatments. This work gives a thorough characterization of non‐resorbable polytetrafluoroethylene films, coated with hydroxyapatite nanoparticles (HAp) through an adhesive coating of self‐polymerized 3,4‐dihydroxy‐DL‐phenylalanine (polyDOPA). This coating technique represents an interesting approach able to improve MC3T3‐E1 pre‐osteoblastic cells adhesion and proliferation on polyDOPA/HAp‐coated substrates.
ISSN:1616-5187
1616-5195
DOI:10.1002/mabi.201500241