Charge-selective claudin channels

Claudins are the main determinants of barrier properties of the tight junction. Many claudins have been shown to act by tightening the paracellular pathway, but several function as paracellular channels. While some depend on the endogenous claudin background of the analyzed cell line, for other clau...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2012-06, Vol.1257 (1), p.20-28
Main Authors: Krug, Susanne M., Günzel, Dorothee, Conrad, Marcel P., Lee, In-Fah M., Amasheh, Salah, Fromm, Michael, Yu, Alan S. L.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Biological Transport - physiology
Biotechnology
Cations
Channels
Chlorides
claudin-10a
claudin-10b
claudin-15
claudin-17
claudin-2
Claudins - chemistry
Claudins - metabolism
Intestines
Kidneys
Membrane Proteins - metabolism
Molecular Sequence Data
Pathways
pore properties
Small intestine
Sodium
Tight Junctions - metabolism
Tightening
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Summary:Claudins are the main determinants of barrier properties of the tight junction. Many claudins have been shown to act by tightening the paracellular pathway, but several function as paracellular channels. While some depend on the endogenous claudin background of the analyzed cell line, for other claudins, a distinct charge‐selectivity has been shown. This paper portrays cation‐selective (claudin‐2, claudin‐10b, claudin‐15) and anion‐selective (claudin‐10a, claudin‐17) claudins and claudins with debatable channel properties (claudin‐4, claudin‐7, claudin‐16). It also describes molecular properties determining the observed charge‐selectivity and pore properties in general. In leaky tissues, they widely determine overall transport characteristics by providing paracellular ion‐selective pathways. In small intestine, claudin‐2 and claudin‐15 replace each other in the developing gut. In kidney proximal tubules, claudin‐2, claudin‐10, and claudin‐17 allow for paracellular reabsorption of sodium, chloride, and water.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2012.06555.x