Oxygen Mass Transport in Stented Coronary Arteries

Oxygen deficiency, known as hypoxia, in arterial walls has been linked to increased intimal hyperplasia, which is the main adverse biological process causing in-stent restenosis. Stent implantation has significant effects on the oxygen transport into the arterial wall. Elucidating these effects is c...

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Bibliographic Details
Published in:Annals of biomedical engineering 2016-02, Vol.44 (2), p.508-522
Main Authors: Murphy, Eoin A., Dunne, Adrian S., Martin, David M., Boyle, Fergal J.
Format: Article
Language:English
Subjects:
Animals
Arteries
Biochemistry
Biological and Medical Physics
Biological Transport, Active
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Biophysics
Boundary layers
Classical Mechanics
Coronary Circulation
Coronary Vessels - metabolism
Coronary Vessels - physiopathology
Design analysis
Design engineering
Devices
Humans
Hypoxia
Implantation
Mass transport
Mathematical models
Medical Stents: State of the Art and Future Directions
Models, Cardiovascular
Oxygen
Stents
Surgical implants
Transport
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Summary:Oxygen deficiency, known as hypoxia, in arterial walls has been linked to increased intimal hyperplasia, which is the main adverse biological process causing in-stent restenosis. Stent implantation has significant effects on the oxygen transport into the arterial wall. Elucidating these effects is critical to optimizing future stent designs. In this study the most advanced oxygen transport model developed to date was assessed in two test cases and used to compare three coronary stent designs. Additionally, the predicted results from four simplified blood oxygen transport models are compared in the two test cases. The advanced model showed good agreement with experimental measurements within the mass-transfer boundary layer and at the luminal surface; however, more work is needed in predicting the oxygen transport within the arterial wall. Simplifying the oxygen transport model within the blood flow produces significant errors in predicting the oxygen transport in arteries. This study can be used as a guide for all future numerical studies in this area and the advanced model could provide a powerful tool in aiding design of stents and other cardiovascular devices.
ISSN:0090-6964
1573-9686
DOI:10.1007/s10439-015-1501-6