Multiscale Control of Hierarchical Structure in Crystalline Block Copolymer Nanoparticles Using Microfluidics

Hierarchical semicrystalline block copolymer nanoparticles are produced in a segmented gas‐liquid microfluidic reactor with top‐down control of multiscale structural features, including nanoparticle morphologies, sizes, and internal crystallinities. Control of multiscale structure on disparate lengt...

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Bibliographic Details
Published in:Macromolecular rapid communications. 2015-11, Vol.36 (22), p.2000-2005
Main Authors: Bains, Aman, Cao, Yimeng, Moffitt, Matthew G.
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Block copolymers
Copolymers
Crystal structure
Crystallization
Dimethylformamide - chemistry
Drug Carriers - chemistry
Drug delivery
Drug delivery systems
Drug Liberation
Flow rate
Flow rates
Mathematical analysis
Microfluidics
Microfluidics - instrumentation
Microfluidics - methods
Microscopy, Electron, Transmission
Nanoparticles
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Paclitaxel - chemistry
Polyesters - chemistry
Reactors
self-assembly
Solutions
Water - chemistry
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Summary:Hierarchical semicrystalline block copolymer nanoparticles are produced in a segmented gas‐liquid microfluidic reactor with top‐down control of multiscale structural features, including nanoparticle morphologies, sizes, and internal crystallinities. Control of multiscale structure on disparate length scales by a single control variable (flow rate) enables tailoring of drug delivery nanoparticle function including release rates. Hierarchical semicrystalline block copolymer nanoparticles are produced in a segmented gas–liquid microfluidic reactor with top–down control of multiscale structural features, including nanoparticle morphologies, sizes, and internal crystallinities. Control of multiscale structure on disparate length scales by a single control variable (flow rate) enables tailoring of drug delivery nanoparticle function including release rates.
ISSN:1022-1336
1521-3927
DOI:10.1002/marc.201500359