Optic neuritis revealing Kikuchi–Fujimoto disease

Kikuchi–Fujimoto disease is a rare systemic disease with uncommon neurological involvement. We report the case of a 30-year-old Asian woman who presented a rapidly progressive loss of vision. Magnetic resonance imaging (MRI) of the optic nerve revealed an inflammation of the left optic nerve with ch...

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Bibliographic Details
Published in:Multiple sclerosis 2014-07, Vol.20 (8), p.1140-1142
Main Authors: Bouquet, F, Maillart, E, Vignal, C, Battistella, M, Meignin, V, Galicier, L, Gout, O
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biopsy
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Diseases of visual field, optic nerve, optic chiasma and optic tracts
Female
Histiocytic Necrotizing Lymphadenitis - complications
Histiocytic Necrotizing Lymphadenitis - diagnostic imaging
Humans
Magnetic Resonance Imaging
Medical sciences
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Ophthalmology
Optic Neuritis - diagnostic imaging
Optic Neuritis - etiology
Optic Neuritis - physiopathology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Tomography, X-Ray Computed
Vision Disorders - etiology
Vision Disorders - physiopathology
Vision, Ocular
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Summary:Kikuchi–Fujimoto disease is a rare systemic disease with uncommon neurological involvement. We report the case of a 30-year-old Asian woman who presented a rapidly progressive loss of vision. Magnetic resonance imaging (MRI) of the optic nerve revealed an inflammation of the left optic nerve with chiasmatic involvement, without any encephalic or medullar lesion. Thoracic computed tomography scan showed bilateral axillary lymphadenopathy. Analysis of a biopsy of the axillary lymph node showed typical histological findings of Kikuchi–Fujimoto disease. There was no clinical or biological sign of associated systemic lupus erythematosus. The patient spontaneously recovered normal visual acuity in 4 weeks, with resolution of MRI abnormalities. No optic neuritis relapse or neurological event occurred in a 3-year follow-up. To our knowledge this is the first case of optic neuritis associated with Kikuchi–Fujimoto disease.
ISSN:1352-4585
1477-0970
DOI:10.1177/1352458514525000