Individualized Hormone Adjustment in the Treatment of Recurrent Spontaneous Abortions

• Published in: Cell biochemistry and biophysics 2015-07, Vol.72 (3), p.817-820
• Main Authors: Shang, Wei, Wang, Aiming, Lv, Libo, Zhang, Lei, Shu, Mingming, Zhao, Yong, Hui, Shang
• Format: Article
• Language: English
• Subjects: Abortion, Habitual - drug therapy; Abortion, Habitual - genetics; Abortion, Habitual - prevention & control; Biochemistry; Biological and Medical Physics; Biomedical and Life Sciences; Biophysics; Biotechnology; Cell Biology; Estrogens; Estrogens - administration & dosage; Estrogens - blood; Estrogens - therapeutic use; Female; Hormones; Humans; Life Sciences; Luteinizing Hormone - administration & dosage; Luteinizing Hormone - blood; Luteinizing Hormone - therapeutic use; Original Paper; Pharmacology/Toxicology; Precision Medicine; Pregnancy; Progesterone - administration & dosage; Progesterone - blood; Progesterone - therapeutic use
• ISSN: 1085-9195; 1559-0283
• DOI: 10.1007/s12013-015-0539-2

Our goal was to develop a safe, efficient, and practical clinical plan for successful pregnancies for patients with recurrent spontaneous miscarriages by adjustment of their hormone levels after ovulation. We treated 61 patients with recurrent miscarriages and 110 patients with two miscarriages. All patients had miscarriages before or during the 12th week of pregnancy, and unsuccessfully underwent progesterone therapy. We measured their hormone levels and administered appropriate doses of estrogen, progesterone, and luteinizing hormones to attain normal levels (respectively, 150 pg/ml, 16 ng/ml, and 6 mIU/ml). The hormone doses were reduced upon detection of fetal heart beating, and the treatment continued until the 12th week of pregnancy. The patients were followed up by phone after the child birth. In patients with recurrent miscarriages, these were prevented in 57/61 (93.44 %). In patients with two miscarriages, successful pregnancies were in 106/110 (96.4 %) patients. The vast majority of patients in both groups gave birth to healthy babies. There was only one case per each group of induced labor due to trisomy 21 (patient with a history of recurrent miscarriages) or trisomy 17 (patient with two previous miscarriages). Individualized adjustment of hormone levels after ovulation prevents miscarriages and improves the pregnancy success rates.