Ipragliflozin effectively reduced visceral fat in Japanese patients with type 2 diabetes under adequate diet therapy

• Published in: Endocrine Journal 2016, Vol.63(6), pp.589-596
• Main Authors: Yamamoto, Chiho, Miyoshi, Hideaki, Ono, Kota, Sugawara, Hajime, Kameda, Reina, Ichiyama, Mei, Yamamoto, Kohei, Nomoto, Hiroshi, Nakamura, Akinobu, Atsumi, Tatsuya
• Format: Article
• Language: English
• Subjects: Adult; Aged; Body Composition - drug effects; Body Mass Index; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - diet therapy; Diabetes Mellitus, Type 2 - drug therapy; Diet therapy; Female; Glucosides - therapeutic use; Humans; Hypoglycemic Agents - therapeutic use; Intra-Abdominal Fat - drug effects; Intra-Abdominal Fat - pathology; Ipragliflozin; Japan; Male; Middle Aged; Obesity - complications; Obesity - diet therapy; Obesity - drug therapy; Thiophenes - therapeutic use; Visceral adipose tissue; Young Adult
• ISSN: 0918-8959; 1348-4540
• DOI: 10.1507/endocrj.EJ15-0749

To investigate if ipragliflozin, a novel sodium-glucose co-transporter 2 inhibitor, alters body composition and to identify variables associated with reductions in visceral adipose tissue in Japanese patients with type 2 diabetes mellitus. This prospective observational study enrolled Japanese participants with type 2 diabetes mellitus. Subjects were administered ipragliflozin (50 mg/day) once daily for 16 weeks. Body composition, visceral adipose tissue volume and plasma variables were measured at 0, 8, and 16-weeks. The subjects’ lifestyle habits including diet and exercise were evaluated at baseline and 16 weeks. The primary endpoint was defined as the decrease of visceral adipose tissue mass. Twenty-four of 26 enrolled participants completed the study. The visceral adipose tissue decreased significantly (110 ± 33 to 101 ± 36 cm2, p = 0.005) as well as other parameters for metabolic insufficiency including hemoglobin A1c. Seventy-one % of the total body weight reduction (-2.49 kg) was estimated by a decrease in fat mass (-1.77 kg), and the remaining reduction (22%) by water volume (-0.55 kg). A minor but significant reduction in the skeletal muscle index was also observed. Correlation analyses were performed to identify variables associated with changes in visceral adipose tissue and the only significant variable identified was diet therapy (Spearman’s r = -0.416, p = 0.043). Ipragliflozin significantly decreased visceral adipose tissue, and improved parametres for metabolic dysfunction. Adequate diet therapy would be necessary to induce and enhance the therapeutic merit.