Decrease of microscopic Plasmodium falciparum infection prevalence during pregnancy following IPTp-SP implementation in urban cities of Gabon

Background Six years after the implementation of intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) in Gabon, its impact on placental malaria and pregnancy outcomes remains unknown. Methods Age, gestational data, use of IPTp-SP and birth weight were recorded du...

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Bibliographic Details
Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene 2016-06, Vol.110 (6), p.333-342
Main Authors: Bouyou-Akotet, M.K., Mawili-Mboumba, D.P., Kendjo, E., Moutandou Chiesa, S., Tshibola Mbuyi, M.L., Tsoumbou-Bakana, G., Zong, J., Ambounda, N., Kombila, M.
Format: Article
Language:English
Subjects:
Adult
Anemia - complications
Anemia - epidemiology
Antimalarials - administration & dosage
Antimalarials - therapeutic use
Birth Weight
Cities
Cross-Sectional Studies
Drug Combinations
Female
Gabon
Gravidity
Humans
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Malaria, Falciparum - epidemiology
Malaria, Falciparum - parasitology
Malaria, Falciparum - prevention & control
Parasitemia - epidemiology
Parasitemia - parasitology
Parasitemia - prevention & control
Placenta
Plasmodium falciparum
Pregnancy
Pregnancy Complications, Parasitic - epidemiology
Pregnancy Complications, Parasitic - parasitology
Pregnancy Complications, Parasitic - prevention & control
Pregnancy Outcome
Prevalence
Pyrimethamine - administration & dosage
Pyrimethamine - therapeutic use
Sulfadoxine - administration & dosage
Sulfadoxine - therapeutic use
Urban Population
Young Adult
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Summary:Background Six years after the implementation of intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) in Gabon, its impact on placental malaria and pregnancy outcomes remains unknown. Methods Age, gestational data, use of IPTp-SP and birth weight were recorded during a hospital-based cross-sectional survey performed in 2011 in 387 women at the end of pregnancy. Results Malaria prevalence was 6.7 and 5.3% in peripheral and placental blood respectively. Overall, 59.0% women took at least two IPTp-SP doses which was associated with 50% reduction of Plasmodium; (P.) falciparum infection in primigravidae. Previous malaria treatment was a risk factor for peripheral P. falciparum infection, while uptake of IPTp-SP was associated with reduced parasitaemia. Anaemia prevalence was 38.0%, low birth weight and prematurity rates were 6.0 and 12.0% respectively. Young age was associated with a higher frequency of malaria, anaemia, low birth weight and preterm delivery (p
ISSN:0035-9203
1878-3503
DOI:10.1093/trstmh/trw034