Role of catalase in the virulence of Brucella melitensis in pregnant goats

An isogenic katE mutant derived from virulent Brucella melitensis 16M displays hypersensitivity to hydrogen peroxide in disk sensitivity assays but retains the capacity to colonize pregnant goats and induce abortion. These experimental findings indicate that although the sole periplasmic catalase of...

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Bibliographic Details
Published in:Veterinary microbiology 2004-08, Vol.102 (1), p.111-115
Main Authors: Gee, Jason M., Kovach, Michael E., Grippe, Vanessa K., Hagius, Sue, Walker, Joel V., Elzer, Philip H., Roop, R.Martin
Format: Article
Language:English
Subjects:
Aborted Fetus - microbiology
Abortion
Abortion, Veterinary - microbiology
Abortion, Veterinary - pathology
Animals
Animals, Newborn - microbiology
Bacteriology
Biological and medical sciences
Brucella
Brucella melitensis
Brucella melitensis - enzymology
Brucella melitensis - genetics
Brucella melitensis - pathogenicity
Brucellosis
Brucellosis - microbiology
Brucellosis - pathology
Brucellosis - veterinary
Catalase
Catalase - genetics
Catalase - metabolism
Catalase - physiology
DNA, Bacterial - chemistry
DNA, Bacterial - genetics
Female
Fundamental and applied biological sciences. Psychology
Goat Diseases - microbiology
Goats
Hydrogen Peroxide - metabolism
Microbiology
Miscellaneous
Mutagenesis, Insertional
Pregnancy
Virulence
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Description
Summary:An isogenic katE mutant derived from virulent Brucella melitensis 16M displays hypersensitivity to hydrogen peroxide in disk sensitivity assays but retains the capacity to colonize pregnant goats and induce abortion. These experimental findings indicate that although the sole periplasmic catalase of Brucella melitensis functions as an antioxidant, this enzyme does not play a critical role in virulence in the natural host.
ISSN:0378-1135
1873-2542
DOI:10.1016/j.vetmic.2004.05.009